以化學或電刺激方式達成卵子活化可提高ICSI完全未受精之受孕率

施行ICSI完全未受精之機率約2-3%
其原因多由於卵子細胞於ICSI過程無法達成活化
以化學或電刺激方式達成卵子活化可提高這類病患之受孕率

http://www.ncbi.nlm.nih.gov/pubmed/12215343?dopt=Abstract

Fertil Steril. 2010 Jul;94(2):520-6. doi: 10.1016/j.fertnstert.2009.03.061. Epub 2009 Apr 25.

Artificial oocyte activation and intracytoplasmic sperm injection.

Nasr-Esfahani MH, Deemeh MR, Tavalaee M.

Source

Isfahan Fertility and Infertility Center, Isfahan, Iran. mh_nasr@med.mui.ac.ir

Abstract

OBJECTIVE:

To review different methods for artificial oocyte activation and its impact on intracytoplasmic sperm injection (ICSI).

DESIGN:

Literature review.

SETTING:

University-based and university-affiliated medical centers.

PATIENT(S):

None.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

None.

RESULT(S):

The ICSI procedure improves fertilization rates in cases of male factor infertility; however, fertilization failure still occurs in 2% to 3% of ICSI cycles. The main cause of failed fertilization is failure to complete oocyte activation. The investigators do not use a variety of mechanical, electrical, and chemical methods to mimic the calcium rise necessary to activate oocytes after ICSI. Chemical activation is the most commonly used method for artificial oocyte activation, resulting in high fertilization rates.

CONCLUSION(S):

Artificial oocyte activation (AOA) may be useful in selected patients who have low fertilization potential. Further studies are required to establish the biosafety of AOA, and clinical tests are needed to evaluate the activation potential of semen samples for proper patient selection.