cAMP細胞內訊號傳遞與卵細胞發育有關

卵泡發育過程中，卵細胞會分泌inhibin, E2，抑制腦下垂體分泌FSH, LH

FSH會刺激卵細胞之adenylyl cyclase, 引發cAMP製造及細胞內訊號傳遞，及進一步卵顆粒細胞及卵細胞之發育
adenylyl cyclase and the production of cAMP
http://www.biolreprod.org/content/65/3/655.full

Follicle Selection in Primates: “Many Are Called but Few Are Chosen”1

1. Anthony J. Zeleznik2

+Author Affiliations

1. Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261

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Abstract

During the follicular phase of humans and most nonhuman primates, a single preovulatory follicle usually matures each menstrual cycle. The observation that numerous preovulatory follicles may be stimulated to mature when exogenous gonadotropins are administered indicates that there must be a precise and highly reproducible mechanism by which only one of the many follicles capable of ovulating actually does so. The goal of this review is to summarize past and current research which indicates that follicle selection in primates is the result of an exquisitely sensitive interplay between gonadotropin secretion by the pituitary gland, steroid production by the ovary, and maturation-dependent alterations of the ovary's responsiveness to gonadotropins.

CONCLUSION

One of the enigmas in understanding the regulation of folliculogenesis is that both FSH and LH, at least in part, regulate follicular function through the cAMP signaling system. If both FSH and LH stimulate cAMP, why is there a need for FSH to induce LH receptors on granulosa cells? Recent findings indicate that the process of preovulatory follicular development, including the selection of a single follicle and ovulation, may be regulated by a single intracellular message (cAMP) which, in turn, is controlled in succession by two different messengers, FSH and LH. These observations, in addition to furthering our basic understanding of ovarian function, may also provide a novel approach for controlled ovarian stimulation in humans. If a specific cutoff point could be identified below which follicles are unresponsive to LH in vivo, it may be possible to develop a sequential FSH-LH stimulation regimen that would be effective in limiting follicular recruitment and thereby reduce the risk of unplanned multiple gestations and ovarian hyperstimulation