PCO病人於施打HCG當天測P4>1.2 or P4<1.2，
卵泡越多，P4可能較高，
P4>1.2與IVF結果無明顯相關
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401251/
Progesterone levels on the hCG day and outcomes in vitro fertilization in women with polycystic ovary syndrome
Abstract
Background
The purpose of this study was to determine the incidence of premature luteinization in patients with polycystic ovary syndrome and compared the main determinants of success in in-vitro fertilization in PCOS patients with and without premature luteinization.
Methods
Retrospective analysis of 180 PCOS women of Chinese Han origin with infertility who underwent controlled ovarian hyperstimulation (COH) with an exogenous gonadotropin/GnRH antagonist protocol. Hormone levels on the hCG day and IVF outcomes were assessed.
Results
The incidence of premature luteinization was 23.3 %. Compared with PCOS patients without premature luteinization, PCOS patients with premature luteinization(PL) had a higher number of oocytes retrieved (18.20
±6.6 vs 15.08±7.3, p=0.037) and a higher fertilization rate (72.9±1.9 vs63.1±2.3, p=0.033), but clinical pregnancy rates were no statistical significance (53.3 vs 56.0, p=0.836). Though the implantation rate was higher in no premature luteinization patients, but the difference was not statistically significant (37.7 vs 30.3, p=0.115).
±6.6 vs 15.08±7.3, p=0.037) and a higher fertilization rate (72.9±1.9 vs63.1±2.3, p=0.033), but clinical pregnancy rates were no statistical significance (53.3 vs 56.0, p=0.836). Though the implantation rate was higher in no premature luteinization patients, but the difference was not statistically significant (37.7 vs 30.3, p=0.115).Conclusion
The PCOS patients with premature luteinization had a higher fertilization rate and high number of oocytes retrieved, and the similar implantation rate and clinical PRs as PCOS patients without premature luteinization.
Table 2
Outcomes in PCOS patients with and without premature luteinization undergoing COH for IVF
| Value | P<1.2 ng/mL (n=138) | P≥1.2 ng/mL (n=42) | p Value |
|---|---|---|---|
| No. of oocytes retrieveda | 15.08±7.3 | 18.20±6.6 | 0.037 |
| No. of day 3 good-quality embryosa | 6.6±3.7 | 7.2±4.7 | 0.475 |
| Good-quality embryo rate (%)a | 67.0±2.3 | 70.9±2.8 | 0.440 |
| No. of embryos transferreda | 2.0±0.8 | 2 .0±0.4 | 0.643 |
| Implantation rate (%)b | 37.7 | 30.3 | 0.115 |
| Fertilization rate (%)a | 63.1±2.3 | 72.9±1.9 | 0.033 |
| Clinical PR (%)b | 56.0 | 53.3 | 0.836 |
aValues are reported as mean±SD and were analyzed by Student’s t test
±SD and were analyzed by Student’s t test
bValues were analyzed by χ2 test
p<0.05 was considered statistically significant
<0.05 was considered statistically significant
IVF in vitro fertilization, COH controlled ovarian hyperstimulation
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