2PN原核荷仁最好>7
Z1----Fig A----最佳
Z2----Fig B----優
Z3----Fig C,D--中
Z4----Fig E,F--差
http://www.ovarianresearch.com/content/6/1/64
Zygote scoring system of Scott et al. [10]. Z1 includes zygotes with equal number of nucleoli aligned at PN junction (A), Z2 includes zygotes with equal number and size of nucleoli (between 3 and 7) which are equally scattered in the two PN (B), Z3 includes zygotes with either very small/large nucleoli (C and D), and Z4 includes zygotes showing PN separated or different in size and small nucleoli, partially aligned or scattered (E and F).
Nicoli et al. Journal of Ovarian Research 2013 6:64 doi:10.1186/1757-2215-6-64
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Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review
Journal of Ovarian Research 2013, 6:64 doi:10.1186/1757-2215-6-64
The electronic version of this article is the complete one and can be found online at:http://www.ovarianresearch.com/content/6/1/64
| Received: | 5 June 2013 |
| Accepted: | 16 August 2013 |
| Published: | 12 September 2013 |
© 2013 Nicoli et al.; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The current systematic review was aimed to assess the effectiveness of the zygote morphology evaluation in fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. All available studies reporting on zygote morphology and clinical and/or biological outcomes were analyzed. Forty studies were included in the final analysis. Fourteen different zygote scoring systems were employed. Zygote morphology correlated significantly with embryo quality and cleavage, blastocyst stage, embryonic chromosome status, in a high proportion of the studies which assessed the specific outcome [15/25 (60%), 15/20 (75%), 7/8 (87.5%), 6/6 (100%), respectively]. On the other hand, only a reduced proportion of papers showed a statistically significant relationship between implantation, pregnancy and delivery/live-birth rates and zygote morphology score [12/23 (52.2%), 12/25 (48%), 1/4 (25%), respectively]. In conclusion, our findings demonstrate the lack of conclusive data on the clinical efficacy of the zygote morphology evaluation in fresh IVF/ICSI cycles, even if biological results showing a good relationship with embryo viability suggest a role in cycles in which the transfer/freezing is performed at day 1.
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