Day2胚葉細胞顯示多核現象之胚胎, 若培養5天後能形成囊胚, 其活產率與正常單核胚葉胚胎活產率類似(59.1% vs. 52.8%). 
培養5天是天然篩選過程, 可自然淘汰染色體不正常之胚胎

J Reprod Dev. 2015;61(6):595-600. doi: 10.1262/jrd.2015-052. Epub 2015 Sep 4.

Developmental capacity and implantation potential of the embryos with multinucleated blastomeres.

Egashira A1, Yamauchi N, Tanaka K, Mine C, Otsubo H, Murakami M, Islam MR, Ohtsuka M, Yoshioka N, Kuramoto T.

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Abstract

The presence of multinucleated blastomeres (MNBs) in embryos is associated with poor developmental competence in assisted reproductive technologies. This phenomenon is observed not only in humans but also in other animal species. The purpose of the present study was to investigate the characteristics of embryos with MNBs (MNB embryos) that could be utilized in embryo transfer. The developmental rate of MNB embryos to the blastocyst stage (50.8%) was significantly lower than that of normal embryos (73.3%) (P < 0.05). The clinical pregnancy rates of fresh embryo transfer (ET) using day 2 or day 3 embryos were significantly lower in MNB embryos (5.1%) compared with normal embryos (24.0%) (P < 0.05). In the case of frozen-thawed ET using a single vitrified/warmed blastocyst, however, the clinical pregnancy rate of MNB embryos was close to that of normal embryos (59.1% vs. 52.8%). Thus, the findings of the present study suggest that the frozen-thawed ET of MNB embryos might improve the potential for implantation followed by successful pregnancy.