胚葉細胞早期(55-70h)融合是胚胎高著床率之重要指標
Day 3胚胎若呈現融合狀態植入後懷孕率高達45-50%



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663968/

J Assist Reprod Genet. 2013 Jun;30(5):683-90. doi: 10.1007/s10815-013-9983-3. Epub 2013 Apr 7.

Early compaction at day 3 may be a useful additional criterion for embryo transfer.

Le Cruguel S1, Ferré-L'Hôtellier V, Morinière C, Lemerle S, Reynier P, Descamps P, May-Panloup P.

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Abstract

PURPOSE:

The reduction of the number of embryos transferred while maintaining a satisfactory rate of pregnancy (PR) with in vitro fertilization calls for a refined technique of embryonic selection. This prospective study investigates the significance of early embryoniccompaction at day 3 as a marker of the chances of implantation.

METHODS:

We examined 317 transfers and their outcome involving 509 embryos including 91 compacted embryos.

RESULTS:

Early compaction seems linked with the ovarian response to stimulation and embryonic quality. The PR is significantly increased when the embryonic cohort contains at least one compacted embryo (44% versus 29.5%, p = 0.01), and when at least one compacted embryo is transferred (44% versus 31%, p < 0.05). The analysis of our single embryo transfers shows that the implantation rates are significantly better for compacted embryos (50% versus 30%, p < 0.05) (OR 2.98; CI 1.02-5.28).

CONCLUSION:

Thus, early compaction, sometimes observed at day 3, may serve as a useful additional criterion for selecting the embryos transferred.