使用超短療程GnRHa(MC第1-4天)併用GnRH antagonist於誘導排卵
可能可改善高齡或反應不佳之誘導排卵病患，取得較多卵子
Fertil Steril. 2008 Jul;90(1):228-30. Epub 2007 Aug 6.
Ultrashort gonadotropin-releasing hormone agonist combined with flexiblemultidose gonadotropin-releasing hormone antagonist for poor responders in in vitro fertilization/embryo transfer programs.
Source
Infertility and IVF Unit, Department of Obstetrics and Gynecology, Barzilai MedicalCenter, Ashkelon 78306, Israel. raoulo@barzi.health.gov.il
Abstract
To evaluate the appropriate controlled ovarian hyperstimulation (COH) protocol in poor responders, we compared the stimulation characteristics of 21 cycles, which included the ultrashort gonadotropin-releasing hormone (GnRH) agonistcombined with the flexible multidose GnRH antagonist, to the patients' previous failed in vitro fertilization attempts. The use of an ultrashort GnRH-agonist/GnRH-antagonist COH protocol resulted in a statistically significantly greater number of follicles larger than 14 mm on the day of hCG administration, a higher number of oocytes retrieved and embryos transferred, and a reasonable clinical pregnancy rate (14.3%).
Fertil Steril. 2009 Apr;91(4 Suppl):1398-400. Epub 2008 Aug 3.
Ultrashort flare GnRH agonist combined with flexible multidose GnRH antagonistfor patients with repeated IVF failures and poor embryo quality.
Source
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel. raoulo@barzi.health.gov.il
Abstract
To evaluate the appropriate controlled ovarian hyperstimulation (COH) protocol in patients with repeated IVF failures and poor embryo quality we compared the stimulation characteristics of ten cycles which included ultrashort flare GnRH agonistcombined with flexible multidose GnRH antagonist with the patients' earlier failed IVF attempts. The use of ultrashort GnRHagonist/GnRH antagonist COH protocol resulted in a significantly higher number and proportion of top-quality embryos, with a consequent improvement in clinical pregnancy rate (50%).
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