2013年4月2日

青春期女性有PCO之比例僅1%


青春期15-19歲女性,確定有多囊性卵巢PCO之比例僅1%
遠低於成年女性

與肥胖有明顯相關

http://www.ncbi.nlm.nih.gov/pubmed/23756098




 2013 Aug;100(2):470-7. doi: 10.1016/j.fertnstert.2013.04.001. Epub 2013 Jun 5.

Prevalence of polycystic ovary syndrome in adolescents.

Source

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.

Abstract

OBJECTIVE:

To investigate the prevalence of polycystic ovary syndrome (PCOS) in adolescents and its association with obesity.

DESIGN:

Cross-sectional study using electronic medical records.

SETTING:

Not applicable.

PATIENT(S):

Adolescents aged 15-19 years (n = 137,502).

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

PCOS diagnosed or defined according to National Institutes of Health (NIH) criteria.

RESULT(S):

The prevalence of a confirmed diagnosis of PCOS was 0.56%, which increased to 1.14% when undiagnosed cases with documented symptoms qualifying for PCOS according to NIH criteria were included. Compared with normal/underweight girls, the odds ratios (OR and 95% confidence interval [CI]) for confirmed PCOS diagnosis were 3.85 (3.04-4.88), 10.25 (8.16-12.84), and 23.10 (18.66-28.61) for overweight, moderately obese, and extremely obese adolescents, respectively, after adjusting for potential confounders. When adolescents with two or more supportive diagnoses were included (diagnosed and undiagnosed PCOS-NIH), the ORs (95% CI) for PCOS-NIH by weight class were significantly attenuated to 2.95 (2.53-3.44), 6.73 (5.78-7.83), and 14.65 (12.73-16.86) for overweight, moderately obese, and extremely obese adolescents, respectively.

CONCLUSION(S):

Overweight and obesity were associated with higher odds of PCOS in adolescents. Studies based solely on diagnosis codes may underestimate the prevalence of PCOS and overestimate the magnitude of the association between obesity and PCOS.

沒有留言:

張貼留言