配合Day 1 & 3胚胎型態可提高預測胚胎優劣之準確度

可從Day 1胚胎型態(Z score)預估Day3Day 1胚胎型態
配合Day 1 & 3胚胎型態可提高預測胚胎優劣之準確度

http://humrep.oxfordjournals.org/content/18/6/1299.long

The predictive value of using a combined Z‐score and day 3 embryo morphology score in the assessment of embryo survival on day 5

1. Kuo‐Chung Lan1, 
2. Fu‐Jen Huang1,3, 
3. Yi‐Chi Lin1, 
4. Fu‐Tsai Kung1,3,
5. Chin‐Hsiung Hsieh1, 
6. Hsuan‐Wei Huang1, 
7. Ping‐Heng Tan2 and
8. Shiuh Young Chang1,3,4

+Author Affiliations

1. ¹Department of Obstetrics and Gynecology,
2. ²Department of Anesthesia, Chang Gung Memorial Hospital, Kaohsiung and
3. ³Medical School, Chang Gung University, Taoyuan, Taiwan

1. 4To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, 123 Ta‐Pei Road, Niaosung Hsiang, Kaohsiung, Taiwan. e‐mail: blue@adm.cgmh.org.tw

• Received December 5, 2002.
• Accepted February 18, 2003.

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Abstract

BACKGROUND: The purpose of this study was to evaluate the ability of using the Z‐score alone, or, in combination with the day 3 embryo morphology score, to predict embryo viability at day 5 from a large cohort of embryos derived from patients undergoing treatment with IVF/ICSI. METHODS AND RESULTS: In this retrospective study, a total of 1894 zygotes from 346 treatment cycles (295 couples) was analysed between January 2001 and May 2002. The Z‐scoring system was useful in predicting day 5 embryo survival. The mean ± SD day 5 embryo survival rates were 78.2 ± 1.7, 49.0 ± 2.5, 21.4 ± 3.2 and 11.8 ± 5.6% for Z‐1, Z‐2, Z‐3 and Z‐4 zygotes groups respectively. Embryos derived from Z‐1 scores and grade I day 3 embryo scores showed the best day 5 embryo survival and a very high implantation potential. CONCLUSIONS: These data suggest that a combined evaluation of the Z‐score and day 3 embryo morphology is highly predictive of embryo outcome after IVF/ICSI. The Z‐score could be of great help in the selection of embryos for cultures extended to later stages. The Z‐score alone, or preferably in combination with day 3 embryo morphology, is useful in the determination of the most suitable embryos and the number of embryos for transfer, thus achieving the optimal chance of conception while reducing the risk of high order multiple pregnancy.

Figure 1. Distribution of Z‐scores for 1894 oocytes.

Figure 3. Relationship between zygote scoring and day 3 morphology.