胚胎分裂速度太慢胚胎染色體常併異常aneuploidy

胚胎分裂速度太慢代表胚胎染色體異常aneuploidy

cell cycle time約 10–12 h 

囊胚染色體異常aneuploidy機率高達50-60%

正常分裂速度

25h+/-2h---2cell

35h+/-2h---3cell

42h+/-2h---4cell

48h+/-3h---5cell

56h+/-3h---8cell

80h+/-4h----compation

95h+/-4h----blastulation

106h+/-4h-- Full blastulation

http://www.sciencedirect.com/science/article/pii/S1472648313000709

Table 2.

Timing of divisions for euploid, single aneuploid and multiple aneuploid embryos.

	Euploid				Single aneuploid					Multiple aneuploid
	25th percentile (hpi)	Median (hpi)	75th percentile (hpi)	n	25th percentile (hpi)	Median (hpi)	75th percentile (hpi)	n	P-value	25th percentile (hpi)	Median (hpi)	75th percentile (hpi)	n	P-value
tPNfaded	20.8	23.2	25.2	32	21.2	23.1	24.8	26	NS	20.8	22.6	23.9	30	NS
t2	23.2	25.1	27.5	38	23.5	25.1	27.4	30	NS	23.3	24.9	26.9	30	0 NS
t3	31.1	35.0	38.3	38	33.4	36.9	39.2	30	NS	33.2	35.6	37.4	30	NS
t5	43.7	48.5	51.5	38	44.9	50.2	52.2	30	NS	43.9	47.7	50.6	30	NS
t8	52.6	56.1	63.1	35	51.2	56.2	60.1	27	NS	48.8	54.0	60.3	27	NS
tSC	74.1	79.7	85.4	35	75.3	80.7	86.7	30	NS	80.1	85.1	89.6	28	0.02∗
tM	79.6	83.5	87.8	32	80.5	87.9	93.6	29	NS	83.9	88.2	94.7	27	NS
tSB	91.7	95.1	101.5	38	96.4	103.4	110.2	30	0.004∗	97.0	101.9	107.3	30	0.006∗∗
tB	101.2	105.9	111.3	38	102.6	109.2	116.0	30	NS	105.9	110.9	116.3	29	0.01∗
tEB	104.5	110.6	114.0	18	105.3	109.2	113.3	13	NS	107.5	115.3	124.9	9	NS
tHB	107.5	109.9	116.6	15	107.3	116.5	120.8	9	NS	114.5	115.4	118.4	6	NS