2015年3月26日

於取卵後D5-7施打3天GnRHantagonist可改善OHSS

於取卵後D5-7施打3天GnRHantagonist可改善卵巢過度刺激OHSS

OHSS造成血液濃稠, MCV>45, WBC>15000, 卵巢>10cm,


http://humrep.oxfordjournals.org/content/22/5/1348.full
http://humrep.oxfordjournals.org/content/28/7/1929.full



Figure 2
Monitoring of (a) ovarian volume, (b) ascites, (c) hematocrit, (d) white blood cells, (e) estradiol and (f) progesterone in patients with severe early OHSS who were administered luteal GnRH antagonist. Oocyte retrieval was performed on Day 0. GnRH antagonist was administered for 3 days, from Day 5 until and including Day 7 post-oocyte retrieval, as indicated by grey boxes on x-axis. Embryo transfer was performed on Day 5. Asterisks depict statistical significance compared with Day 5 (*P < 0.05; **P < 0.01; ***P < 0.001).





Pregnancy outcomes for the high-risk patients who either did not develop severe OHSS (control) or developed severe OHSS and were administered GnRH antagonist in the luteal phase (OHSS + antag).
OHSS + antag (n = 22)Control (n = 172)P
Positive hCG test, n (%)16 (72.7)129 (75.0)0.798
Clinical, n (%)11 (50.0)112 (65.1)0.239
Ongoing, n (%)10 (45.5)84 (48.8)0.834
Live birth, n (%)9 (40.9)75 (43.6)1.000
Biochemical pregnancy5/16 (31.3)17/129 (13.2)0.070
Clinical spontaneous abortion1/11 (9.1)27/112 (24.1)0.453
Multiple pregnancy6/16 (37.5)57/129 (44.2)0.790

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