人工授孕懷孕率約15%
影響人工授孕懷孕率主因為: 女性年齡, 不孕原因, 精蟲品質, 排卵針劑量

Int J Fertil Steril. 2015 Oct-Dec;9(3):300-308. Epub 2015 Oct 31.

Evaluating The Effective Factors in Pregnancy after Intrauterine Insemination: A Retrospective Study.

Ghaffari F1, Sadatmahalleh SJ2, Akhoond MR3, Eftekhari Yazdi P4, Zolfaghari Z1.

Author information

Abstract

BACKGROUND:

Controlled ovarian hyperstimulation (COH) in conjunction with intrauterine inseminations (IUI) are commonly used to treat infertile couples. In this study we evaluated the relationship between IUI outcome and special causes of infertility. We also aimed to examine parameters that might predict success following IUI.

MATERIALS AND METHODS:

In this cross-sectional study, we included 994 IUI cycles in 803 couples who referred to the infertility Institute. All statistical analyses were performed by using SPSS program, t tests and chi-square. Stepwise multiple linear regression analysis was performed to compare the association between dependent and independent variables. Logistic regression was conducted to build a prediction model of the IUI outcome.

RESULTS:

Overall pregnancy rate per completed cycle (16.5%) and live birth rate per cycle (14.5%). The mean age in the pregnant group was significantly lower than that of the non-pregnant group (P=0.01).There was an association between cause of infertility and clinical pregnancies (P<0.001). Logistic regression identified four significant factors in determining the success of the IUI [menstrual irregularites (OR:2.3, CI:1.6-3.4, P<0.001), duration of infertility (OR:0.8, CI:0.8-0.9, P<0.001), total dose of gonadotropin (OR:1.02, CI:1.003-1.04, P=0.02) and semen volume (OR:1.1, CI:1.008-1.2, P=0.03)] which were the most predictive of IUI success.

CONCLUSION:

Our study defined prognostic factors for pregnancy in COH+IUI. These variables can be integrated into a mathematical model to predict the chance of pregnancy rate in subsequent COH+IUI cycles.