子宮內膜異位瘤重複開刀對卵巢功能影響更大
應謹慎考慮改採保守療法避免一再開刀下降卵巢功能

Fertil Steril. 2015 Mar;103(3):738-43. doi: 10.1016/j.fertnstert.2014.12.101. Epub 2015 Jan 7.

Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery.

Muzii L1, Achilli C2, Lecce F2, Bianchi A3, Franceschetti S2, Marchetti C2, Perniola G2, Panici PB2.

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Abstract

OBJECTIVE:

To evaluate the excised specimen with histologic analysis and to assess the antral follicle count (AFC) at follow-up. This is to determine whether excisional surgery for recurrent endometriomas is more harmful to ovarian tissue and to the ovarian reserve than first surgery.

DESIGN:

Prospective controlled study.

SETTING:

University hospital.

PATIENT(S):

Consecutive patients with pelvic pain and/or infertility undergoing laparoscopic excision of a monolateral ovarian endometrioma for the first time (17 patients) or for recurrence after previous surgery (11 patients).

INTERVENTION(S):

Laparoscopic excision of ovarian endometrioma and ultrasonographic evaluation 3 months after surgery.

MAIN OUTCOME MEASURE(S):

Cyst wall histologic evaluation (specimen thickness, presence and morphology of ovarian tissue) and evaluation of ovarian reserve with AFC and ovarian volumes of both the operated and contralateral, nonoperated ovary at follow-up.

RESULT(S):

The cyst wall specimen was significantly thicker in the recurrent endometrioma group than in the first surgery group (1.7 ± 0.3 mm vs. 1.1 ± 0.3 mm). Both main components of the cyst specimen (i.e., endometriosis tissue and ovarian tissue) were more represented in the recurrent endometrioma group than in the first surgery group. At sonographic follow-up, the operated ovary had a significantly lower AFC and volume than the contralateral nonoperated ovary in the recurrent endometrioma group, but not in the primary surgery group.

CONCLUSION(S):

Surgery for recurrent endometriomas is associated with evidence of a higher loss of ovarian tissue and is more harmful to the ovarian reserve evaluated by AFC and ovarian volume, if compared with endometriomas operated for the first time. Indications to surgery for recurrent endometriomas should be reconsidered with caution.