Autophagy在卵巢冷凍解凍移植過程扮演部分角色
包括清除壞死卵子細胞, 細胞凋亡, 抗血管血栓

Biol Reprod. 2016 Feb 24. pii: biolreprod.115.136374. [Epub ahead of print]

New Insights into the Role of Autophagy in Ovarian Cryopreservation by Vitrification.

Yang Y, Cheung HH, Law WN, Zhang C, Chan WY, Pei X, Wang Y.

Abstract

Ovarian cryopreservation by vitrification is a highly useful method for preserving female fertility during radiotherapy and chemotherapy. However, cryo-injury, osmotic stress during vitrification, and ischemia/reperfusion during transplantation lead to losses of ovarian follicles. Ovarian follicle loss may be partially reduced by several methods; however, studies regarding the mechanism of ovarian follicle loss have only investigated cell apoptosis, which comprises type I programmed cell death. Autophagy comprises type II programmed cell death, and cell homeostasis is maintained by autophagy during conditions of stress. The role of autophagy during cryopreservation by vitrification has rarely been reported. The potential role of autophagy during ovarian cryopreservation by vitrification is reviewed in this article.