懷孕早期子宮肌瘤生長較懷孕中期快速
此與懷孕早期賀爾蒙HCG濃度快速上升有關

Fertil Steril. 2016 Feb 12. pii: S0015-0282(16)00073-X. doi: 10.1016/j.fertnstert.2016.01.032. [Epub ahead of print]

Growth trend of small uterine fibroids and human chorionic gonadotropin serum levels in early pregnancy: an observational study.

Ciavattini A1, Delli Carpini G2, Clemente N2, Moriconi L2, Gentili C2, Di Giuseppe J2.

Author information

Abstract

OBJECTIVE:

To analyze the growth trend of small uterine fibroids during early pregnancy, evaluating the potential factors involved, with particular interest in hCG levels.

DESIGN:

Observational study.

SETTING:

Tertiary care university hospital.

PATIENT(S):

Women who had an ultrasound diagnosis of small myomas (diameter, ≥10 mm and ≤50 mm) from January 2007 to December 2013, and who subsequently became pregnant within 1 year.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Three additional ultrasound examinations were performed during early pregnancy (7-8, 10-13, and 20-22 complete gestational weeks, respectively) and the modifications in diameter and volume of each uterine fibroid were recorded. A serial evaluation of hCG serum levels from 5-12 weeks was performed.

RESULT(S):

From the 109 women who fulfilled the study inclusion/exclusion criteria, a significant increase emerged, both for volume and diameter of the detected fibroids. Specifically, a median growth rate (GR) of 122% was observed during the interval of the first to the second ultrasound, whereas a median GR of 108% was detected during the interval between the second and the third ultrasound, and a median GR of 25% between the third and the fourth ultrasound. A significant positive correlation between hCG levels and diameter (R = 0.69) of myomas between 5 and 12 weeks emerged.

CONCLUSION(S):

A remarkable nonlinear growth of small fibroids during initial pregnancy was observed, with a faster rate in the first trimester and a slowdown by midpregnancy. Those changes seem to be related to the similar increase of hCG levels until 12 weeks.