胚胎植入前於子宮腔內注射hCG可提高懷孕率

高齡(>40歲)不孕症病患施行試管嬰兒胚胎植入過程前
於子宮腔內注射少量hCG (100-500IU)
可能可提高胚胎著床率與懷孕率
from: http://www.ncbi.nlm.nih.gov/pubmed/22047664

Fertil Steril. 2011 Nov 1. [Epub ahead of print]

Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves the implantation and pregnancy rates in in vitro fertilization/intracytoplasmic sperm injection: a prospective randomized study.

Mansour R, Tawab N, Kamal O, El-Faissal Y, Serour A, Aboulghar M, Serour G.

Source

The Egyptian IVF-ET Center, Cairo, Egypt.

Abstract

OBJECTIVE:

To investigate the value of intrauterine injection of human chorionic gonadotropin (hCG) before embryo transfer (ET).

DESIGN:

Prospective randomized study.

SETTING:

The Egyptian IVF-ET Center.

PATIENT(S):

Infertility patients younger than 40 years undergoing their first in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).

INTERVENTION(S):

The study group (n = 167) received either 100 IU of hCG (n = 83), or 200 IU of hCG (n = 84) via intrauterine administration before ET. The control group (n = 93) underwent ET without hCG. After the interim analysis, the modified study group (n = 107) received intrauterine injection of 500 IU of hCG, and the control group (n = 105) underwent ET without hCG.

MAIN OUTCOME MEASURE(S):

Clinical pregnancy rate (PR) and implantation rate (IR).

RESULT(S):

The IR and PR were statistically significantly higher in the 500 hCG group (41.6% and 75%, respectively) as compared with the control group (29.5% and 60%, respectively). The IR and PR were 26.6% and 54% in the 100 hCG group, 28.3% and 57% in the 200 IU hCG group, and 29.4% and 60% in the control group, respectively, with no statistically significant difference.

CONCLUSION(S):

Intrauterine injection of 500 IU of hCG before ET statistically significantly improved the implantation and pregnancy rates in IVF/ICSI.