精蟲活動力與玻尿酸篩選法(HBA)關連

雖然玻尿酸法可篩選出活動力與型態較佳之精蟲
玻尿酸法
使用玻尿酸篩選精蟲於傳統試管嬰兒治療之效果並不明確

from: http://humrep.oxfordjournals.org/content/21/6/1545.full.pdf

Hum Reprod. 2006 Jun;21(6):1545-50. Epub 2006 Apr 4.

 

Hum Reprod. 2006 Jun;21(6):1545-50. Epub 2006 Apr 4.

Relationship between human sperm-hyaluronan binding assay and fertilization rate in conventional in vitro fertilization.

Ye H, Huang GN, Gao Y, Liu de Y.

Source

Reproductive and Genetics Institute, Chongqing Obstetrics and Gynecology Hospital, Chongqing, China.

Abstract

BACKGROUND:

Sperm-hyaluronan-binding assay (HBA) is one of the commercial kits being marketed for routine testing of sperm maturity and fertility. However, there is no report of whether the HBA can provide additional information over standard semen analysis for sperm-fertilizing ability. The objective of this study was to investigate the relationship between HBA and fertilization rate in conventional IVF.

METHODS:

A total of 175 IVF patients with > or = 3 mature oocytes inseminated were included in the study. Both the standard semen analysis and the HBA were performed on the same ejaculated sperm samples used for IVF treatments. Relationships between the semen analysis and the HBA results and fertilization rate were analysed by both the Spearman test and the multivariate logistic regression analysis.

RESULTS:

Both total and progressive sperm motility and normal morphology were highly correlated with HBA scores. While both normal sperm morphology and HBA scores were statistically significantly related to fertilization rates, the HBA was less significant than normal sperm morphology. The HBA does not provide additional information for identifying patients with a poor fertilization rate.

CONCLUSION:

HBA is highly significantly correlated with sperm motility and morphology but is less significant than sperm morphology in relation to the fertilization rate in IVF. Thus, the clinical predictive value of HBA for sperm-fertilizing ability in vitro is limited.

精蟲活動力與HBA關連

Correlation between hyaluronan-binding assay (HBA) and sperm total motility (A, n = 175, Spearman r = 0.506, P < 0.001),

精蟲前進活動力與HBA關連

progressive motility (B, n = 175, Spearman r = 0.442, P < 0.001) 

精蟲形態與HBA關連

 normal sperm morphology (C, n = 175, Spearman r = 0.217, P < 0.01).

 HBA與試管受孕率之關連

Correlation between hyaluronan-binding assay (HBA) (n = 175, Spearman r = 0.224, P < 0.01) and fertilization rate in IVF.