Day 7胚胎仍有27%著床率

Day 7 胚胎冷凍解凍仍有79%存活率，27%著床率



Fertil Steril. 2013 Jul 19. pii: S0015-0282(13)00720-6. doi: 10.1016/j.fertnstert.2013.06.021. [Epub ahead of print]

Should embryos developing to blastocysts on day 7 be cryopreserved and transferred: an analysis of pregnancy and implantation rates.

Kovalevsky G, Carney SM, Morrison LS, Boylan CF, Neithardt AB, Feinberg RF.

Source

Reproductive Associates of Delaware, Newark, Delaware. Electronic address: gkovalevsky@gmail.com.

Abstract

OBJECTIVE:

To compare pregnancy rates (PRs) using blastocysts cryopreserved on day 7 with those cryopreserved on days 5 and 6.

DESIGN:

Retrospective observational cohort study.

SETTING:

Infertility center performing IVF.

PATIENT(S):

Eight hundred women with infertility undergoing frozen ET.

INTERVENTION(S):

Blastocysts cryopreserved on days 5, 6, and 7 after retrieval were thawed and transferred.

MAIN OUTCOME MEASURE(S):

Ongoing PRs (pregnancy developing appropriately into the second trimester). Thaw survival, implantation rates, and clinical PRs were also calculated.

RESULT(S):

A total of 1,406 embryos were thawed with a survival of 90.7% for day 5, 83.7% for day 6, and 78.7% for day 7. Implantation rates were 43.3%, 28.9%, and 28.9%, respectively. Ongoing PRs were 43.9%, 32.9%, and 26.7%, respectively.

CONCLUSION(S):

Blastocysts cryopreserved on day 7 have a lower, but clinically important potential. Embryos that do not achieve blastocyst stage on day 6 should not be universally discarded, but should be observed in culture 1 more day as 27% may result in an ongoing pregnancy.