高劑量類固醇(20mg)治療重複習慣性流產

子宮內膜自然殺手細胞 natural killer (NK) cells可能導致習慣性流產
本篇使用高劑量類固醇 (20mg, 5mg qid)，成功治療NK cell 造成之重複流產14次之習慣性流產病患


http://humrep.oxfordjournals.org/content/18/12/2562.full

Successful pregnancy outcome following 19 consecutive miscarriages: Case report

1. Siobhan Quenby1,4, 
2. Roy Farquharson3, 
3. Michelle Young1 and 
4. Gill Vince2

+Author Affiliations

1. Departments of
2. ¹Obstetrics and Gynaecology and
3. ²Immunology, University of Liverpool, Liverpool L69 3BX and
4. ³Liverpool Women’s Hospital, Crown Street, Liverpool L8 7SS, UK

1. 4To whom correspondence should be addressed. e‐mail: squenby@liv.ac.uk

• Received June 24, 2003.
• Revision received August 7, 2003.
• Accepted September 4, 2003.

 

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Abstract

No cause can be found in 50% of patients with recurrent miscarriage. Recent research has shown that high levels of natural killer (NK) cells within the endometrium may be associated with idiopathic recurrent miscarriage. This case report describes a patient in whom an excessive number of uterine NK cells were found. She received preconceptual prednisolone and delivered a live baby. This is a novel observation of untested significance.