試管嬰兒趨勢為更廣泛使用玻璃化冷凍及解凍胚胎植入

試管嬰兒未來之趨勢為更加廣泛使用玻璃化冷凍及解凍胚胎植入
尤其針對卵巢過度刺激或子宮內膜狀況不佳之病人

本篇指出，冷凍及解凍胚胎植入vs. 新鮮胚胎植入之懷孕率分別為 39 vs. 28%


http://www.springerlink.com/content/t46775m9x71tn113/

J Assist Reprod Genet. 2010 Jul;27(7):357-63. Epub 2010 Apr 6.

Can fresh embryo transfers be replaced by cryopreserved-thawed embryotransfers in assisted reproductive cycles? A randomized controlled trial.

Aflatoonian A, Oskouian H, Ahmadi S, Oskouian L.

Source

Research and Clinical Center for Infertility, Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Science, Safaieh, Yazd, Iran. abbas_aflatoonian@yahoo.com

Abstract

PURPOSE:

Controlled ovarian hyperstimulation has been shown to advance endometrial maturation and adversely affects implantation in ART. It has been reported that there is a better embryo-endometrium synchrony in frozen-thawed embryotransfer cycles than fresh embryo transfer cycles. The objective of this study was to compare ongoing pregnancy rates between fresh ET and FET cycles.

METHODS:

In an open prospective, controlled study, the patients who were classified as high responders, were randomizedto either fresh ET or FET. The embryos in FET group were cryopreserved with vitrification by Cryotop method.

RESULTS:

A total of 374 patients were included, 187 of which were randomized to FET and 187 to fresh ET. There were 39% (n = 73) ongoing pregnancy in FET group compared with 27.8% (n = 52) in fresh ET group[odds ratio = 1.66;95% confidence interval = 1.07-2.56; p = 0.02].

CONCLUSIONS:

FETs can be performed instead of fresh ETs to improve the outcome of ART in highly selected patients.