大劑量咖啡飲酒可能造成流產

大劑量的攝取酒精可能造成懷孕早期流產
中低劑量的飲酒與早期流產無明顯關聯

中大劑量的咖啡因(咖啡，茶，可可)攝取可能造成懷孕早期流產
低劑量的攝取咖啡因與流產無明顯關聯

http://humrep.oxfordjournals.org/content/18/12/2704.full

Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion?

1. J.S. Tolstrup1,2, 
2. S.K. Kjær3,6, 
3. C. Munk3, 
4. L.B. Madsen3, 
5. B. Ottesen4,
6. T. Bergholt5 and 
7. M. Grønbæk1,2

+Author Affiliations

1. ¹Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Kommunehospitalet, DK‐1399, Copenhagen,
2. ²Centre for Alcohol Research, National Institute of Public Health, Svanemollevej 25, DK‐2100, Copenhagen,
3. ³Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK‐2100, Copenhagen,
4. ⁴Department of Obstetrics and Gynaecology, Hvidovre University Hospital, Kettegaard Alle 30, DK‐2650, Hvidovre and
5. ⁵Department of Obstetrics and Gynaecology, Hillerod Hospital, Helsevej 2, DK‐3400, Hillerød, Denmark

1. 6To whom correspondence should be addressed. e‐mail: susanne@cancer.dk

• Received March 10, 2003.
• Revision received May 21, 2003.
• Accepted August 19, 2003.

 

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Abstract

BACKGROUND: Consumption of caffeine and alcohol is suspected to affect pregnancy outcome. Use of both stimulants is widespread and even minor effects on fetal viability are of public health interest. METHODS: We performed a nested case–control study using prospective data from a population‐based cohort comprising 11 088 women aged 20–29 years. From this cohort, women who experienced either a spontaneous abortion (n = 303) or who gave birth (n = 1381) during follow‐up [mean time: 2.1 years (range: 1.6–3.4)] were selected. Associations between self‐reported exposures to caffeine and/or alcohol at enrolment and spontaneous abortion were analysed by means of logistic regression. RESULTS: Compared with women with a pre‐pregnancy intake of <75 mg caffeine per day, the adjusted odds ratio (95% confidence interval) for spontaneous abortion was 1.26 (0.77–2.06), 1.45 (0.87–2.41), 1.44 (0.87–2.37) and 1.72 (1.00–2.96) for a pre‐pregnancy intake on 75–300, 301–500, 501–900 and >900 mg caffeine per day respectively (P = 0.05 for trend). A pre‐pregnancy intake of alcohol was not a predictor for spontaneous abortion. CONCLUSIONS: A high intake of caffeine prior to pregnancy seems to be associated with an increased risk of spontaneous abortion, whereas a low‐to‐moderate alcohol intake does not influence the risk.