基因合成FSH vs.尿液提煉FSH

基因合成FSH (rFSH)vs尿液提煉FSH(uFSH))，
在胚胎受孕率，胚胎著床率，胚胎品質---rFSH 優於uFSH
卵泡數量---uFSH多於rFSH

http://humrep.oxfordjournals.org/content/19/2/306.full

Table I.

Ovarian responses of women receiving rFSH or uFSH stimulation

	Gonadotrophin administered		P
	rFSH	uFSH
No. of cycles	151	135
Age (years)	33.1 ± 5.0	32.6 ± 4.7	0.395
Primary/secondary infertility	115/36	109/26	0.343
Duration of infertility (years)	4.4 ± 3.2	4.5 ± 3.2	0.721
Ampoules of 75 IU FSH	29.3 ± 10.2	31.4 ± 10.9	0.116
Units of FSH administered	2198 ± 775	2389 ± 817	0.113
Days of FSH treatment	9.3 ± 1.6	9 ± 1.5	0.102
Endometrial thickness on day of hCG (cm)	1.23 ± 0.25	1.23 ± 0.29	0.913
Estradiol (pg/ml) on hCG day	1340 ± 878	1660 ± 1427	0.033
Follicles ≥16 mm in diameter on hCG day	3.3 ± 2.2	4.2 ± 2.9	0.011
Follicles ≥13 mm in diameter on hCG day	7.1 ± 4.2	9.3 ± 4.6	<0.001
No. of oocytes retrieved	5.6 ± 3.2	7.4 ± 4.8	<0.001

Table III.

Ovarian responses and treatment outcomes in the same patients receiving rFSH and uFSH stimulation respectively

	Gonadotrophin administered		P
	rFSH (n = 18)	uFSH (n = 18)
No. of cycles	19	18
Age (years)	33.2 ± 4.0	32.2 ± 4.4	0.454
Ampoules of 75 IU FSH	27.9 ± 5.6	30.9 ± 6.3	0.159
Units of FSH administered	2129 ± 452	2365 ± 486	0.158
Days of FSH treatment	8.7 ± 1.4	8.4 ± 0.9	0.499
Endometrial thickness on day of hCG (cm)	1.2 ± 0.3	1.2 ± 0.3	0.858
Estradiol (pg/ml) on hCG day	1641 ± 1135	1845 ± 1580	0.660
Follicles ≥16 mm in diameter on hCG day	3.9 ± 2.3	4.2 ± 3.2	0.807
Follicles ≥13 mm in diameter on hCG day	8.8 ± 4.4	8.2 ± 4.5	0.683
No. of oocytes retrieved	6.6 ± 3.7	7.0 ± 4.4	0.754
No. of embryos transferred	3.4 ± 1.5	3.6 ± 1.2	0.715
No. of good embryos transferred	2.5 ± 1.2	2.8 ± 1.1	0.463
Pregnancy rate/transfer (%)	8 (44.4)	4 (22.2)	0.157
Implantation rate (%)	14/61 (23)	5/64 (7.8)	0.019