子宮內膜異位手術明顯減少取卵數

子宮內膜異位手術會明顯造成試管嬰兒取卵數減少
但對於卵子受孕率及胚胎植入後懷孕率較不明顯

http://www.ncbi.nlm.nih.gov/pubmed/16690058

Fertil Steril. 2006 Jun;85(6):1730-5. Epub 2006 May 11.

Outcome of in vitro fertilization/intracytoplasmic sperm injection after laparoscopic cystectomy for endometriomas.

Esinler I, Bozdag G, Aybar F, Bayar U, Yarali H.

Source

Department of Obstetrics and Gynecology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Abstract

OBJECTIVE:

To assess the impact of prior unilateral or bilateral endometrioma cystectomy on controlled ovarian hyperstimulation (COH) and intracytoplasmic sperm injection (ICSI) outcome.

DESIGN:

Retrospective case-control study.

SETTING:

Department of Obstetrics and Gynecology, School of Medicine, Hacettepe University, Ankara, Turkey.

PATIENT(S):

Fifty-seven consecutive infertile patients were enrolled who had previously undergone unilateral (n = 34) or bilateral (n = 23) laparoscopic cystectomy for endometriomas more than 3 cm in diameter and underwent ICSI. The control group consisted of 99 patients with tubal factor infertility.

INTERVENTION(S):

Controlled ovarian hyperstimulation and ICSI.

MAIN OUTCOME MEASURE(S):

Cycle cancellation rate, number of oocytes, fertilization rate, embryo quality, clinical pregnancy rate (PR), and implantation rate.

RESULT(S):

The mean number of oocytes, metaphase II oocytes, and two-pronucleated oocytes were significantly lower in the bilateral cystectomy group compared to the unilateral cystectomy and control groups. However, all other parameters, including fertilization rate, the mean number of embryos transferred, the mean number of grade 1 embryos transferred, the clinical PR per embryo transfer, and implantation rate, were comparable among the three groups. Within the unilateral cystectomy group, the mean number of oocyte retrieved from the operated site was significantly less than in the contralateral nonoperated site.

CONCLUSION(S):

Laparoscopic endometrioma cystectomy does reduce the ovarian reserve. However, diminished ovarian reserve does not translate into impaired pregnancy outcome.