破卵後施行AIH可達較高懷孕率

破卵後施行人工授精vs破卵前施行人工授精可達較高懷孕率 (24 vs 9%)

精蟲游動速度約 1cm/min, 15-20分鐘即可從子宮游到卵巢

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582119/

Intrauterine insemination: is the timing correct?

Tansu Kucuk

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Abstract

Objective

To evaluate the impact of follicle rupture on pregnancy rate in intrauterine insemination.

Material and method

Retrospective cohort study. Evidence of follicle rupture was assessed by transvaginal ultrasonography following IUI. Two hundred ninety-six couples with unexplained infertility and 121 couples with male factor subfertility were included. Results of 578 cycles were analyzed here.

Result

Clinical pregnancy rate was 23.5% (64/272) in the group when follicle rupture was evident by transvaginal ultrasonography, while it was only 8.8% (27/306) when follicle rupture was not evident (p<0.001).

Conclusion

Postponing IUI until observation of follicle rupture may yield a higher pregnancy rate.

Table 1

Comparisons of subgroups

	Follicle rupture cycles n:272			No rupture cycles n:306			p Sub A vs Sub C	p Sub B vs Sub D	p Sub A + Sub B vs Sub C + Sub D
	Pregnant Sub A n:64	Non-pregnant Sub B n:208	p	Pregnant Sub C n:27	Non-pregnant Sub D n:279	p
Age (years)	27.7±5.5	28.7±4.9	NS	28.2±6.9	26.7±4.2	NS	NS	NS	NS
Day 3 FSH (IU/L)	7.2±1.9	7.4±2.2	NS	6.9±2.1	8.2±1.1	NS	NS	NS	NS
Duration of infertility (months)	21.5±4.0	24.2±2.9	NS	22.5±5.2	23.8±3.2	NS	NS	NS	NS
TMS (106)	19.2±6.6	22.1±5.4	NS	21.2±8.2	26.1±7.8	NS	NS	NS	NS
No of follicle >17 mm	2.4±1.1	2.4±1.7	NS	2.9±1.2	2.1±1.2	NS	NS	NS	NS
Pregnancy	64/272			27/306			<0.001

Comparisons were made by using ×2 test and student t test where appropriate