MTX對卵巢功能無明顯不良影響

單一劑量MTX治療子宮外孕，對卵巢功能無明顯不良影響與長期後遺症.

http://www.ncbi.nlm.nih.gov/pubmed/23891021

Fertil Steril. 2013 Jul 24. pii: S0015-0282(13)00740-1. doi: 10.1016/j.fertnstert.2013.06.040. [Epub ahead of print]

Effect of single-dose methotrexate on ovarian reserve in women with ectopic pregnancy.

Uyar I, Yucel OU, Gezer C, Gulhan I, Karis B, Hanhan HM, Ozeren M.

Source

Aegean Obstetrics and Gynecology Education and Research Hospital, İzmir, Turkey. Electronic address: iuyar03@yahoo.com.

Abstract

OBJECTIVE:

To evaluate ovarian reserve in women with ectopic pregnancy treated with single-dose systemic methotrexate in the early post-treatment period.

DESIGN:

Prospective study.

SETTING:

Women's health education and research hospital.

PATIENT (S):

Eighty-two patients with ectopic pregnancy and 80 healthy women in the same age group were included in the study. Of the 82 patients, 49 with ectopic pregnancy were treated with single-dose systemic methotrexate (MTX) and 33 were treated surgically with laparoscopy or laparotomy (salpingectomy or salpingostomy).

INTERVENTION(S):

Ovarian reserve testing.

MAIN OUTCOME MEASURE(S):

Basal FSH on the 3rd day of the menstrual cycle, E2, basal antral follicle count (AFC), and ovarian volume.

RESULT(S):

There were no differences among the groups in terms of basal FSH, E2, AFC, and ovarian volume.

CONCLUSION(S):

The single-dose MTX treatment had no effect on ovarian reserve in women with ectopic pregnancy as measured by the above-mentioned parameters.

Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Ovarian reserve, ectopic pregnancy, methotrexate treatment