破卵針33或39小時AIH懷孕率無明顯差異

破卵針打完後33小時 vs. 39小時施行人工授孕，懷孕率並無明顯統計差異 (21 vs.15%) http://www.ncbi.nlm.nih.gov/pubmed/15236979





Fertil Steril. 2004 Jul;82(1):13-6.

Timing intrauterine insemination either 33 or 39 hours after administration of human chorionic gonadotropin yields the same pregnancy rates as after superovulation therapy.

Claman P, Wilkie V, Collins D.

Source

Department of Obstetrics and Gynecology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada. pclaman@ottawa.hospital.on.ca

Abstract

OBJECTIVE:

To compare a short and long interval between hCG administration and IUI after superovulation for the treatment of infertility.

DESIGN:

Prospective, randomized clinical trial.

SETTING:

University hospital-based fertility clinic.

PATIENT(S):

Patients planning superovulation and IUI for the treatment of infertility.

INTERVENTION(S):

Patients with >or=2 years of infertility enrolled for superovulation and IUI treatment were randomized to IUI after a short (32-34-hour) or long (38-40-hour) interval after hCG injection. Superovulation was accomplished with hMG or recombinant FSH, with dose adjustment until the maturation of two to five follicles, at which time hCG was given. Sperm was prepared with a gradient centrifugation technique, with IUI performed high up in the uterine fundus.

MAIN OUTCOME MEASURE(S):

Pregnancy rates.

RESULT(S):

Of the 348 patient cycles randomized, 270 treatment cycles were initiated. Eighty-one initiated cycles were canceled, leaving 189 completed randomized cycles from 75 patients for analysis. Pregnancy rates were not significantly different between groups. There were pregnancies in 20 of the 96 short hCG-IUI interval cycles (21%) and in 14 of the 93 long hCG-IUI interval cycles (15%) (odds ratio = 0.673, 95% confidence interval 0.297-1.518).

CONCLUSION(S):

Pregnancy rates are the same after superovulation therapy whether IUI is done after a short or a long interval after hCG injection.