排卵藥可能提高卵泡未排卵症候群發生比率

卵泡未排卵症候群luteinized unruptured follicle (LUF) syndrome

打完破卵針後仍不排卵，佔不孕症5-10%
佔不明原因不孕症20-25%

使用排卵藥可能提高卵泡未排卵症候群發生比率

http://humrep.oxfordjournals.org/content/21/8/2110.long

Luteinized unruptured follicle syndrome: incidence and recurrence rate in infertile women with unexplained infertility undergoing intrauterine insemination

1. H. Qublan¹,³, 
2. Z. Amarin², 
3. M. Nawasreh¹, 
4. F. Diab¹, 
5. S. Malkawi¹,
6. N. Al-Ahmad¹ and 
7. M. Balawneh¹

+Author Affiliations

1. ¹Department of Obstetrics and Gynaecology, Prince Rashid Hospital, Royal Medical Services, Irbid, Jordan and
2. ²Department of Obstetrics and Gynaecology, Jordan University of Science and Technology, Irbid, Jordan

1. 3To whom correspondence should be addressed at: Irbid-Aidoun, P.O. Box 97, Irbid 21166, Jordan. E-mail: hqublan@yahoo.com

• Received February 2, 2006.
• Revision received March 12, 2006.
• Accepted March 22, 2006.

 

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Abstract

BACKGROUND: The objective of this study was to determine the incidence and recurrence rate of luteinized unruptured follicle (LUF) syndrome in women with unexplained infertility undergoing intrauterine insemination (IUI). METHODS: A total of 167 women with unexplained infertility who underwent 292 cycles of IUI were enrolled in the study. All patients were treated with clomiphene citrate, 50–150 mg/daily from day 5 to 9 of their menstrual cycle. Ultrasound examination to confirm ovulation was performed on the day of IUI (day 0) and every day thereafter for another 3 days (days 1, 2 and 3). A total of 69 women who failed to conceive in the first cycle and 56 women who failed to conceive in the second cycle underwent second and third cycles, respectively. RESULTS: Of the total 167 patients who underwent first cycle, 42 (25%) had LUF. The incidence of LUF was 56.5% in 69 patients who underwent a second cycle of IUI treatment, of whom 33 patients had LUF in the first cycle with recurrence rate of 78.6%. In 56 patients who underwent 3 consecutive cycles, the incidence of LUF was 58.9% and recurrence rate of 90%. No pregnancies were recorded in patients with LUF during the study period. CONCLUSION: The incidence and recurrence rate of LUF are significantly increased in subsequent cycles of IUI. In these patients, other options of infertility treatment might be justified.