卵巢反應良好的病患其P4濃度>1.0 ng/mL懷孕率不一定下降

施打破卵針當天P4濃度>1.0 ng/mL (about 3.2 nmol/L) 
可能代表過早黃體化Premature luteinization
本篇質疑破卵針當天P4濃度其預測懷孕結果之準確性

卵巢反應良好的病患其P4濃度>1.0 ng/mL 懷孕率不一定會下降
若卵巢反應不佳合併P4濃度>1.0 ng/mL 懷孕率可能會下降

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719067/

Does subtle progesterone rise on the day of HCG affect pregnancy rate in long agonist ICSI cycles?

Hisham Ali Saleh,1,2,3 Mervat Sheikh El-Arab Omran,1,2 and Mohamed Draz1

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Abstract

Purpose

To evaluate the impact of subtle progesterone (P4) rise on the day of HCG on pregnancy outcome in ICSI patients stimulated with long agonist protocol.

Methods

One hundred forty-nine consecutive controlled ovarian hyperstimulation cycles for ICSI using long luteal agonist protocol.

Results

Mean serum progesterone on day of hCG was 0.88±0.51 ng/mL values ≥1 ng/mL were found in 34.2% of cycles. Serum E2 on day of hCG and number of oocytes retrieved were significantly higher in the group with P4≥1 ng/mL. The area under ROC for serum progesterone in prediction of pregnancy was 0.52, indicating that within the values studied, serum progesterone on day of hCG is not predictive of pregnancy outcome.

Conclusion

P4 values ≥1 ng/mL on day of hCG are common in long agonist ICSI cycles particularly with high response. Within the P4 values encountered in this study, implantation and pregnancy rates are not adversely affected.