合併hCG+GnRHa破卵活產率略低於hCG破卵

使用hCG1500iu+GnRHa 0.1ml破卵 vs. hCG 10000iu破卵
活產率24% vs. 31%

合併hCG1500iu+GnRHa 0.1ml破卵 ，活產率略低於傳統破卵

http://www.ncbi.nlm.nih.gov/pubmed/19200959?dopt=Abstract

Fertil Steril. 2010 Feb;93(3):847-54. doi: 10.1016/j.fertnstert.2008.12.042. Epub 2009 Feb 6.

1,500 IU human chorionic gonadotropin administered at oocyte retrieval rescues the luteal phase when gonadotropin-releasing hormone agonist is used for ovulation induction: a prospective, randomized, controlled study.

Humaidan P, Ejdrup Bredkjaer H, Westergaard LG, Yding Andersen C.

Source

The Fertility Clinic, Skive Regional Hospital, Resenvej 25, 7800 Skive, Denmark. peter.humaidan@sygehusviborg.dk

Abstract

OBJECTIVE:

To prospectively assess the reproductive outcome with a small bolus of hCG administered on the day of oocyte retrieval after ovulation induction with a GnRH agonist (GnRHa).

DESIGN:

Prospective, randomized trial.

SETTING:

Three hospital-based IVF clinics.

PATIENT(S):

Three hundred five IVF/intracytoplasmic sperm injection patients after a GnRH antagonist protocol.

INTERVENTION(S):

Ovulation induction was performed with either 10,000 IU hCG or 0.5 mg GnRHa (buserelin) supplemented with 1,500 IU hCG on the day of oocyte retrieval.

MAIN OUTCOME MEASURE(S):

Reproductive outcome in the two groups.

RESULT(S):

No significant differences were seen regarding positive hCG/ET rate (48% and 48%), ongoing pregnancy rate (26% and 33%), delivery rate (24% and 31%), and rate of early pregnancy loss (21% and 17%) between the GnRHa and 10,000 IU hCG groups, respectively.

CONCLUSION(S):

A small bolus of hCG in the GnRHa group secured the luteal phase, resulting in a comparable reproductive outcome in the two groups. However, a nonsignificant difference of 7% in delivery rates justifies further studies to refine the use of GnRHa for ovulation induction.