AMH>3.5 OHSS機率較高

AMH>3.5時，卵巢過度刺激OHSS機率較高

體重過重, AMH可能會降低

AMH非絕對準確，偽陽性率約10-20%

http://www.ncbi.nlm.nih.gov/pubmed/22487725



http://ovidsp.tx.ovid.com/sp-3.10.0b/ovidweb.cgi?QS2=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

Curr Opin Obstet Gynecol. 2012 Jun;24(3):151-7. doi: 10.1097/GCO.0b013e3283527dcf.

Is the measurement of anti-Müllerian hormone essential?

Usta T, Oral E.

Source

Department of Obstetrics & Gynecology, Bagcilar Education and Research Hospital, Istanbul, Turkey.

Abstract

PURPOSE OF REVIEW:

Over the past decade, a large number of studies examining the multiple roles of anti-Müllerian hormone (AMH) have been published. The purpose of this article is to focus on the clinical usefulness of AMH in the fields of current gynecological clinical practice.

RECENT FINDINGS:

AMH has entered clinical practice in terms of poor ovarian response definition. It prevents folliculogenesis by reducing follicle sensitivity to follicle-stimulating hormone (FSH), and leads to anovulation when secreted in excess amounts in polycystic ovary syndrome (PCOS). Better results might be obtained in the assisted reproductive technique cycle in the presence of high AMH levels even though FSH is increased in women diagnosed with diminished ovarian reserve. In a more recently published study it has been reported that AMH can also predict the outcome of pregnancy in assisted reproduction.

SUMMARY:

AMH levels accurately reflect the ovarian follicular reserve and might, therefore, be considered as a sensitive marker of ovarian aging and ovarian reserve. Evaluation of the level of AMH has clinical value in predicting the success of in-vitro fertilization (IVF). Hyper-response/ovarian hyperstimulation syndrome (OHSS) might be anticipated as about 3.5 ng/ml or above. The cycle stability and operator independency make AMH a most appealing single marker of ovarian reserve. Use of AMH to paint tailored stimulation protocol could result in a reduced risk of OHSS, optimized treatment burden and maintained pregnancy rates. Cost-effectiveness of the use of AMH as a single test before initiating an IVF program should be determined.