AIDS感染導致精液品質下降

AIDS感染病人之精液品質(體積，濃度，活動力)亦會下降
應施予抗AIDS藥劑治療，使精液中之AIDS病毒下降到不可偵測時才可考慮施予人工受孕
一方面提高人工受孕懷孕率，亦下降AIDS感染率

http://humrep.oxfordjournals.org/content/19/10/2289.full

The effect of human immunodeficiency virus on sperm parameters and the outcome of intrauterine insemination following sperm washing

1. James D.M. Nicopoullos1,3, 
2. Paula A. Almeida1, 
3. Jonathan W.A. Ramsay1,2and 
4. Carole Gilling-Smith1

+Author Affiliations

1. ¹Assisted Conception Unit, Chelsea & Westminster Hospital, London SW10 9NH and ²Clinical Director of Surgery, Charring Cross Hospital, London W6 8RF, UK

1. 3To whom correspondence should be addressed. Email:james.nicopoullos@chelwest.nhs.uk

• Received April 13, 2004.
• Accepted June 26, 2004.

 

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Abstract

BACKGROUND: This is the first study to assess the outcome of sperm washing and intrauterine insemination (IUI) cycles in human immunodeficiency virus-positive (HIV⁺) men to determine any predictors of success, as well as evaluating the effect of HIV on sperm parameters. METHODS: Semen characteristics were evaluated in 106 HIV⁺ men and a control group of 234 HIV⁻ men, and the effect of markers of HIV disease assessed. Age, stimulation regime, sperm parameters, markers of HIV disease and the use of anti-retrovirals were assessed as predictors of the outcome of sperm washing/IUI cycles in the HIV⁺ men. RESULTS: Ejaculate volume, sperm concentration, total count, progressive motility and normal morphology were all significantly higher in the control group compared to the HIV⁺ men (P<0.05). A significant positive correlation was observed between CD4 count and sperm concentration, total count, motility, progressive motility type ‘a’+‘b’ and post-preparation concentration and a significant negative correlation with normal sperm morphology of both raw and post-preparation samples. No correlation was observed between viral load (VL), years since diagnosis, use of anti-retrovirals or duration of use and any sperm parameter. The only factors that significantly improved IUI outcome were a VL <1000 copies/ml and the use of anti-retrovirals. CONCLUSIONS: These data demonstrate that sperm parameters are significantly impaired by the presence of HIV infection and in particular correlate with CD4 count. Undetectable VL and the use of anti-retrovirals improve the outcome of IUI/sperm washing in HIV⁺ men.