軟性胚胎植入管懷孕率較高

胚胎植入(ET)管之比較
軟性ET管較少造成子宮內膜損傷
軟性ET管懷孕率較高
http://humrep.oxfordjournals.org/content/20/11/3114.full

Soft versus firm embryo transfer catheters for assisted reproduction: a systematic review and meta-analysis*

1. Ahmed M. Abou-Setta ¹ , ³ , 
2. Hesham G. Al-Inany ¹ , ² , 
3. Ragaa T. Mansour ¹, 
4. Gamal I. Serour ¹ and 
5. Mohamed A. Aboulghar ¹ , ²

+Author Affiliations

1. ¹The Egyptian IVF–ET Center, 3, Street 161, Hadayek El Maadi, Cairo 11431 and ²The Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt

1. 3To whom correspondence should be addressed: E-Mail: abousetta_md@hotmail.com;ivf@link.net

• Received April 21, 2005.
• Revision received June 12, 2005.
• Accepted June 16, 2005.

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Abstract

BACKGROUND: The true impact of the embryo transfer catheter choice on an IVF programme has not been fully examined. We therefore decided to systematically review the evidence provided in the literature so that we may evaluate a single variable in relation to a successful transfer, the firmness of the embryo transfer catheter. METHODS: An extensive computerized search was conducted for all relevant articles published as full text, or abstracts, and critically appraised. In addition, a hand search was undertaken to locate any further trials. RESULTS: A total of 23 randomized controlled trials (RCT) evaluating the types of embryo transfer catheters were identified. Only ten of these trials, including 4141 embryo transfers, compared soft versus firm embryo catheters. Pooling of the results demonstrated a statistically significantly increased chance of clinical pregnancy following embryo transfer using the soft (643/2109) versus firm (488/2032) catheters [P = 0.01; odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.08–1.79]. When only the truly RCT were analysed, the results were again still in favour of using the soft embryo transfer catheters [soft (432/1403) versus firm (330/1402)], but with a greater significance (P < 0.00001; OR = 1.49, 95% CI = 1.26–1.77). CONCLUSION: Using soft embryo transfer catheters for embryo transfer results in a significantly higher pregnancy rate as compared to firm catheters.

Figure 3.

Meta-analysis of clinical pregnancy rates for all RCTs (random effects model), Truly RCTs (fixed effect model) and fresh IVF cycles only (random effects model.)