可提高排卵率與懷孕率
http://humrep.oxfordjournals.org/content/17/2/289.full
Table III.
The ovarian response and pregnancy rates during rFSH treatment using low dose the step-up protocol
| Placebo (n = 15) | Metformin (n = 10) | |
|---|---|---|
All comparisons between the placebo and metformin groups are not significant.
Figure 1.
Numbers of women who ovulated and/or conceived in response to metformin/placebo only or combined with rFSH treatment. *P < 0.05.
| ||
| Duration of stimulation (day) | 19.7 ± 10.8 | 17.1 ± 7.8 |
| Total dose (IU) | 2062.5 ± 1397.1 | 1607.8 ± 887.1 |
| No. of vials | 27.5 ± 18.6 | 21.4 ± 11.8 |
| Estradiol on the day of HCG (pg/ml) | 543.5 ± 619.9 | 509.1 ± 246.0 |
| Endometrial thickness on the day of HCG (mm) | 9.7 ± 1.7 | 10.0 ± 1.3 |
| Monofollicular development (%) | 8 (53.3) | 5 (50.0) |
| Multifollicular development (%) | 7 (46.7) | 5 (50.0) |
| Ovulation (%) | 11 (73.3) | 9 (90.0) |
| Pregnancy per cycle (%) | 1 (6.7) | 3 (30.0) |
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