賀爾蒙間之相對數值與平衡比個別賀爾蒙之絕對數值同等重要

人體眾多賀爾蒙之間之相對數值與平衡性比個別賀爾蒙之絕對數值同等重要
過去只提出FSH/LH之相對比值，本篇提出FSH/E2之相對比值
不同個體對賀爾蒙之需求亦不相同，不同年齡對LH之需求亦不相同
因此誘導排卵之劑量使用需考量不同年齡與狀況而定

http://humrep.oxfordjournals.org/content/23/5/1004.full

Ovarian function: a theory of relativity

1. Andrea Weghofer1,2,4 and 
2. Norbert Gleicher2,3

+Author Affiliations

1. ¹Department of Obstetrics and Gynecology, Medical University Vienna, Waehringer Guertel 18–20, 1090 Vienna, Austria
2. ²The Center for Human Reproduction, New York, The Foundation for Reproductive Medicine, New York, NY, USA
3. ³Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

1. 4Correspondence address. Tel: +43-1404002822; Fax: +43-1404002993; E-mail:andrea.weghofer@meduniwien.ac.at

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Abstract

Kol and Homburg recently hypothesized in these pages that the change, rather than currently evaluated absolute hormone values, is important for biological processes. We fully agree, but wish, with this communication, to add to their concept: opposing forces, balancing each other, in order to maintain a system's stability, permeates nature. Loss of such equilibrium, in turn, results in systemic malfunctions with, at times, adverse consequences. Extrapolating to Kol and Homburg's hypothesis, this observation would suggest that not only changes in any given hormone carry biological messages, but that final message derives from hormonal ratios between hormones which oppose each other in physiological effects. In full concurrence to Kol and Homburg, this concept could give rise to better diagnosis and treatment of infertility problems.