每日施予FSH比間隔性FSH更能促進卵泡之發育

鼠胚研究顯示，每日持續給予FSH(10 mIU/ml FSH)比間隔性的FSH更能促進未成熟卵泡之發育

http://humrep.oxfordjournals.org/content/19/2/398.full

Figure 1. Development and differentiation of a representative follicle cultured for 12 days in the continuous presence of 10 mIU/ml FSH. Early preantral follicles (follicular stage) are put into culture and after 4 days the follicles develop to late preantral follicles (diffuse stage). During the second half of the culture period the follicle mural and cumulus cell differentiation becomes apparent, resulting in the formation of antral‐like cavities (antral stage). The follicles differentiate into pre‐ovulatory follicles. Eighteen hours after the ovulation stimulus (given on day 12), mucified cumulus–oocyte complexes are free‐floating in the culture droplet.

Figure 4. The morphological appearance of representative follicles out of each experimental condition on day 12 of culture (magnification ×400).