2012年12月5日

中心體在卵子受孕過程扮演重要角色

精子或卵子中心體在卵子受孕過程扮演重要角色
中心體與紡錘體運作正常與否有關
中心體異常與否與胚胎染色體是否異常aneuploidy有關

http://www.reproduction-online.org/content/142/6/793.full

Figure 1
Figure 1
Schematic diagram of centriole complex in sperm and duplication after fertilization. The sperm's centriole complex primarily consisting of a prominent proximal centriole surrounded by sparse centrosomal material and a distal centriole that becomes degraded along with the sperm tail after fertilization (reviewed in Schatten & Sun (2009a2009b)). γ-Tubulin, pericentrin, and centrin are among the centrosomal proteins that have been identified around the proximal sperm centriole. Duplication of centrioles takes place at the pronuclear stage followed by separation of the duplicated centriole–centrosome complex and migration around the zygote nucleus to the opposite poles to form the centers of the mitotic spindle poles.



Figure 2
Figure 2
Schematic diagram of MII spindle in oocytes before fertilization. The MII spindle is organized by acentriolar centrosomes that nucleate kinetochore and pole-to-pole microtubules for separation of chromosomes.

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