PCO併男性賀爾蒙過高時臨床症狀較為嚴重

PCO診斷3指標: 月經異常, PCO, 男性賀爾蒙過高
其中2項出現即成立

PCO併男性賀爾蒙過高時，臨床症狀通常較為嚴重，常合併metabolic syndrome
包括較高之insulin, TG, etc

http://humrep.oxfordjournals.org/content/23/8/1924.full

Clinical and biochemical characteristics of polycystic ovary syndrome in Korean women

1. Soo Jin Chae1, 
2. Jin Ju Kim1, 
3. Young Min Choi1,2,3, 
4. Kyu Ri Hwang1,
5. Byung Chul Jee1,2, 
6. Seung Yup Ku1,2, 
7. Chang Suk Suh1,2, 
8. Seok Hyun Kim1,2,
9. Jung Gu Kim1 and 
10. Shin Yong Moon1,2

+Author Affiliations

1. ¹Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110–744, South Korea
2. ²Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea

1. 3Correspondence address. Fax: +82-2-762-3599; E-mail: ymchoi@snu.ac.kr

• Received March 29, 2008.
• Revision received May 16, 2008.
• Accepted May 23, 2008.

 

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Abstract

BACKGROUND We investigated the differences in anthropometrical, hormonal and insulin resistance parameters according to the subtype of polycystic ovary syndrome (PCOS) in Korean women.

METHODS We recruited 166 women with PCOS and retrospectively recruited 277 controls. PCOS was diagnosed by irregular menstruation (IM), polycystic ovary (PCO) and hyperandrogenism (HA). Subjects were divided into four subgroups: the IM/HA/PCO group (n = 87, 52.4%), the IM/PCO group (n = 52, 31.3%), the IM/HA group (n = 23, 13.9%) and the HA/PCO group (n = 4, 2.4%). Clinical and biochemical variables were compared among the PCOS subgroups.

RESULTS The IM/HA/PCO and IM/HA groups showed higher body mass index (P < 0.001) and waist-to-hip ratio (P < 0.001) than the IM/PCO group. The IM/HA group had higher triglyceride levels than the other groups (P < 0.001). Higher fasting insulin (P < 0.001) and postprandial 2 h insulin (P < 0.01) were noted in the IM/HA/PCO group and the IM/HA group, compared with the IM/PCO group. Women with PCOS showed lower sex hormone-binding globulin (P < 0.001) and higher systolic blood pressure (BP) (P = 0.004), diastolic BP (P = 0.001), fasting insulin (P< 0.001), postprandial 2 h insulin (P < 0.001), homeostatic model for insulin resistance (P < 0.001) and clinical and biochemical parameters of metabolic syndrome (P < 0.05) compared with subjects without PCOS.

CONCLUSIONS Women with PCOS without HA are common in Korea and are less likely to have metabolic dysfunction, insulin resistance and elevated BP. PCOS without HA may be a mild phenotype of PCOS. Therefore, women with PCOS in Korea could have a reduced likelihood of having metabolic syndrome compared with women of other ethnicities.