PGD失敗錯誤率約10%

PGD基因放大偵測過程失敗錯誤率約10%

Genotype un-diagnosed	28 (10%)
Amplification failure	14 (5%)
Allele drop-out	14 (5%)

http://humrep.oxfordjournals.org/content/28/5/1435.full

Table III

Blastocyst biopsy, vitrification and thawed embryo transfer for monogenic diseases.

Couples	33
OPU cycles	40
Mature oocyte number	566 (14 ± 8)
Normally fertilized oocytes	436 (77%)
Embryos biopsied	272 (62%)
Genotype diagnosed	244 (90%)
Unaffected	158 (65%)
Affected	86 (35%)
Genotype un-diagnosed	28 (10%)
Amplification failure	14 (5%)
Allele drop-out	14 (5%)
Cycles of frozen-thawed ET	38
Embryos thawed	68
Embryos survived after thawing	64 (94%)
Number of embryos transferred	64
Mean embryos transferred/transfer cycle	1.7 ± 0.5
Implantation rate	32/64 (50%)
Clinical pregnancy rate per OPU cycle	25/40 (63%)
Ongoing pregnancy rate per OPU cycle	24/40 (60%)

• OPU, ovum pick-up; ET, embryo transfer. Data are expressed as the mean ± standard deviation.