IVF過程使用高劑量賀爾蒙會提高靜脈栓塞之風險

J Hum Reprod Sci. 2015 Jul-Sep;8(3):182-5. doi: 10.4103/0974-1208.165150.

Deep venous thrombosis in a patient undergoing In-vitro fertilization with oocyte donation.

Mahajan N1, Naidu P1, Gupta S1, Rani K1.

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Abstract

Deep venous thrombosis (DVT) has been reported extensively following ovarian hyperstimulation syndrome during in-vitro fertilization (IVF). Pregnancy per se increases the risk of DVT due to a hypercoagulable state. The long-term use of hormone replacement therapy (HRT) is another critical factor associated with DVT in women. However, an association between the short-term use of HRT in oocyte donation (OD) cycles and DVT has not yet been reported. We present a case of 43-year-old woman who developed DVT after IVF-OD. DVT was diagnosed at 7 weeks of pregnancy and was managed with low-molecular-weight heparin. We suggest that even a short-term use of HRT should be considered a risk factor for DVT especially in the presence of additional risk factors such as obesity. The patient had an uneventful recovery and delivered three healthy though preterm babies.