Zygote arrest與胚胎原核及細胞質型態有關

Day1胚胎受孕後停止分裂(Zygote arrest)
與Day1胚胎原核型態及細胞質型態有關

http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8394168

Day 1胚胎原核與極體等級與胚胎品質無明顯關連

Day 1胚胎原核與極體等級與胚胎品質無明顯關連

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902489/?tool=pubmed

Day1&2胚胎細胞核狀況無法有效預測胚胎懷孕率

Day1胚胎原核PN狀況(Z score) & Day2胚胎細胞核狀況無法有效預測胚胎品質與懷孕率

http://www.ncbi.nlm.nih.gov/pubmed/21316045?dopt=Abstract&holding=f1000,f1000m,isrctn

胚胎原核無法有效預測胚胎品質

Day1胚胎原核PN無法有效預測胚胎品質

http://informahealthcare.com/doi/abs/10.3109/09513590.2010.509829

配合Day 1 & 3胚胎型態可提高預測胚胎優劣之準確度

可從Day 1胚胎型態(Z score)預估Day3Day 1胚胎型態
配合Day 1 & 3胚胎型態可提高預測胚胎優劣之準確度

http://humrep.oxfordjournals.org/content/18/6/1299.long

Day 3胚胎植入懷孕率優於Day 1胚胎植入

Day 3胚胎植入懷孕率優於Day 1胚胎植入

Day 1胚胎挑選Z score準確度不盡理想

http://humrep.oxfordjournals.org/content/19/3/645.long

原核Z-score對預估胚胎懷孕率成效有限

原核PN評估Z-score, 對於胚胎植入後之懷孕率預估成效有限

2PN原核荷仁最好>7
Z1----Fig A----最佳
Z2----Fig B----優
Z3----Fig C,D--中
Z4----Fig E,F--差

http://www.ovarianresearch.com/content/6/1/64

Zygote scoring system of Scott et al. [10]. Z1 includes zygotes with equal number of nucleoli aligned at PN junction (A), Z2 includes zygotes with equal number and size of nucleoli (between 3 and 7) which are equally scattered in the two PN (B), Z3 includes zygotes with either very small/large nucleoli (C and D), and Z4 includes zygotes showing PN separated or different in size and small nucleoli, partially aligned or scattered (E and F).

Nicoli et al. Journal of Ovarian Research 2013 6:64   doi:10.1186/1757-2215-6-64
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Pronuclear morphology evaluation for fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles: a systematic review

Alessia Nicoli, Stefano Palomba^*, Francesco Capodanno, Maria Fini, Angela Falbo andGiovanni Battista La Sala

• *Corresponding author: Stefano Palomba stefanopalomba@tin.it

Author Affiliations

Department of Obstetrics, Gynecology and Pediatrics, A.O. Arcispedale S. Maria Nuova, IRCCS, University of Modena and Reggio Emilia, Viale Risorgimento 80, 42123 Reggio Emilia, Italy

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Journal of Ovarian Research 2013, 6:64  doi:10.1186/1757-2215-6-64

The electronic version of this article is the complete one and can be found online at:http://www.ovarianresearch.com/content/6/1/64

Received:	5 June 2013
Accepted:	16 August 2013
Published:	12 September 2013

© 2013 Nicoli et al.; licensee BioMed Central Ltd. 

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The current systematic review was aimed to assess the effectiveness of the zygote morphology evaluation in fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles. All available studies reporting on zygote morphology and clinical and/or biological outcomes were analyzed. Forty studies were included in the final analysis. Fourteen different zygote scoring systems were employed. Zygote morphology correlated significantly with embryo quality and cleavage, blastocyst stage, embryonic chromosome status, in a high proportion of the studies which assessed the specific outcome [15/25 (60%), 15/20 (75%), 7/8 (87.5%), 6/6 (100%), respectively]. On the other hand, only a reduced proportion of papers showed a statistically significant relationship between implantation, pregnancy and delivery/live-birth rates and zygote morphology score [12/23 (52.2%), 12/25 (48%), 1/4 (25%), respectively]. In conclusion, our findings demonstrate the lack of conclusive data on the clinical efficacy of the zygote morphology evaluation in fresh IVF/ICSI cycles, even if biological results showing a good relationship with embryo viability suggest a role in cycles in which the transfer/freezing is performed at day 1.

Keywords: 

ARTs; Embryo; ICSI; IVF; Morphology; Zygote

合併day1, 2 & 3 embryo score可挑選出最佳胚胎，提高著床率

Z score: 評估原核胚胎之方法:

  

Day-1 PN score (Z score)可有效預測胚 胎品質與囊胚比率

 

1. Day-1 PN score (Z-score)可有效預測胚胎品質與囊胚比率 (囊胚比率: 48% vs. 30%)
2. 但Day-1 PN score (Z score)無法完全準確挑選胚胎以提高懷孕率 (22 vs 14%)