2012年5月3日

卵泡細胞之生長從原始卵子到成熟需3個月的時間

卵泡細胞之生長從原始卵子到成熟需3個月的時間

FSH window: 濾泡期早期誘導排卵所需FSH最低劑量

http://edrv.endojournals.org/content/18/1/71.full



  Figure 1.
Figure 1.
Schematic representation of human ovarian follicle development. Primordial follicles entering the growth phase form primary follicles (class 1). This is followed by gonadotropin-independent (tonic) growth (class 1 to 4), and eventually gonadotropin (Gn)-dependent growth. Note that the overall development from a class 1 to a class 5 follicle takes three cycles [Reproduced with permission from A. Gougeon].


  Figure 6.
Figure 6.
Schematic representation of the intercycle rise in serum FSH levels (FSH threshold/window concept), and follicle growth dynamics (recruitment, selection, and dominance) during the follicular phase of the normal menstrual cycle (upper panel). FSH serum levels during the follicular phase of gonadotropin induction of ovulation using a step-down dose regimen (starting dose of 150 IU/day) are depicted in the middle panel. FSH serum levels and follicle growth during the 7-day pill-free interval following combined steroid contraceptive pills (OAC) are indicated in the lower panel. The FSH threshold is the serum level required for stimulation of ovarian activity. The FSH window represents the number of days when FSH concentrations remain above the threshold. Recruitment represents the transition from gonadotropin-independent to gonadotropin-dependent follicle development (follicles are rescued from their destiny to undergo atresia by the intercycle rise in FSH). Selection refers to the process where a single follicle gains dominance over the remaining follicles from the recruited cohort.


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