卵泡成長到晚期添加HMG或LH有助於提高懷孕率

卵泡成長到晚期(>1.4cm)添加HMG或LH有助於提高懷孕率

http://www.ncbi.nlm.nih.gov/pubmed?term=Commenges%E2%80%90Ducos%20M%2C%20Piault%20S%2C%20Papax

Fertil Steril. 2002 Nov;78(5):1049-54.

Recombinant follicle-stimulating hormone versus human menopausal gonadotropin in the late follicular phase during ovarian hyperstimulation for in vitro fertilization.

Commenges-Ducos M, Piault S, Papaxanthos A, Ribes C, Dallay D, Commenges D.

Source

Department of Obstetrics and Gynaecology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France. monique.commenges@chu-bordeaux.fr

Abstract

OBJECTIVE:

To study the effect of exogenous LH in the late follicular phase on ongoing pregnancies and at the different stages of IVF-ET (stimulation, fertilization, and implantation) in patients with low endogenous LH.

DESIGN:

Retrospective cohort study with modeling of the different phases of IVF-ET.

SETTING:

IVF center of the teaching hospital in Bordeaux, France.

PATIENT(S):

Women undergoing IVF and ICSI treatment.

INTERVENTION(S):

One group received recombinant FSH alone (FSH group) and the other received recombinant FSH and hMG in the late follicular phase (i.e., when the largest follicle reached 14 mm) (FSH/hMG group).

MAIN OUTCOME MEASURE(S):

Ongoing pregnancy, number of oocytes, and number of embryos.

RESULT(S):

The FSH/hMG group had a higher probability of having at least one oocyte (odds ratio [OR] = 2.75 [1.11-6.80]), of having at least one embryo after oocyte retrieval (OR = 2.84 [1.33-6.07]), and of ongoing pregnancy after ET (OR = 2.04 [0.83-5.01]), and globally had a higher probability of ongoing pregnancy (OR = 2.83 [1.19-6.71]).

CONCLUSION(S):

In ovarian hyperstimulation for IVF-ET, LH supplementation in the late follicular phase of women with low endogenous LH is beneficial for ongoing pregnancy by increasing the rate of success of all stages of the treatment.