精蟲差施行ICSI 後比精蟲正常施行ICSI懷孕率為低

精蟲差的病人施行ICSI 後懷孕率比精蟲正常的病人施行ICSI後懷孕率為低

原因可能在於精蟲差的病人施行ICSI可能挑選到有問題的精蟲機率較高，進而影響胚胎之著床率

http://www.ncbi.nlm.nih.gov/pubmed/18582871

Fertil Steril. 2009 Mar;91(3):798-804. Epub 2008 Jun 25.

Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen-thawed cycles: potential paternal effects on pregnancy outcomes.

Lee SH, Song H, Park YS, Koong MK, Song IO, Jun JH.

Source

Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea.

Abstract

OBJECTIVE:

To evaluate objectively whether poor sperm quality affects sequential events from fertilization to delivery in fresh intracytoplasmic sperm injection (ICSI) and subsequent frozen-thawed embryo transfer (ET) cycles.

DESIGN:

Retrospective study.

SETTING:

University-based centers for reproductive medicine.

PATIENT(S):

For unbiased comparison, 206 cycles were chosen from 1,999 cycles of patients who underwent ICSI-ET and/or subsequent frozen-thawed ET. Cycles met the following criteria: day 3 ET; female age, <40 y; number of retrieved oocytes, >or=5; no split insemination; and no female factors but tubal factor.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

The rates of fertilization, embryo implantation, clinical pregnancy, and delivery and sequential embryonic score (SES) were compared between normal-spermatogenesis patients (NSPs) and defective-spermatogenesis patients (DSPs).

RESULT(S):

Although sum SES, mean SES, and top SES of transferred embryos on day 3 were similar between NSPs and DSPs, the rates of implantation, clinical pregnancy, and delivery of NSPs were significantly higher than those of DSPs. Furthermore, subsequent ET cycles with frozen-thawed embryos in NSPs and DSPs who failed to achieve pregnancy in their fresh cycles showed that rates of implantation and clinical pregnancy also were significantly lower in DSPs.

CONCLUSION(S):

Quality of sperm may influence embryo implantation and subsequent pregnancy outcomes without impairment of embryo quality.