胚胎植入之深度達子宮腔上1/3或中1/3與懷孕率或著床率無明顯關聯
Eur J
Obstet Gynecol Reprod Biol. 2012 Mar 15. [Epub ahead of print]
Does it really matter how far from the fundus embryos are transferred?
Source
Kaali Institute IVF Center, Budapest, Hungary.
Abstract
OBJECTIVE:
Embryo transfer (ET) is an important last step
during the process of IVF. Over the years much has been learned about the
importance of the details of this procedure including the potential impact of
transfer depth on outcome. The objective of our
study was to evaluate whether transfer depth
assessed by air bubble location after ET is associated with clinical
outcome.
STUDY DESIGN:
Retrospective analysis of the association between transfer distance from the fundus (assessed by air bubble
location after ET) and IVF outcome based on cycles (N=409) of patients with good
prognosis undergoing infertility treatment for various indications. Treatments
followed standard stimulation, IVF-ICSI and ET procedures. The distance of the
air bubble as a surrogate marker of embryo location
after transfer was measured and was correlated with
implantation (IR) and pregnancy rates (PR) after day 3 and day 5 ET. Univariate
comparisons were performed by nonparametric methods and multiple logistic
regression was used to further evaluate the association between pregnancy rate
and those factors that might influence outcome.
RESULTS:
The distance of the bubble was similar in those cycles that led to a
pregnancy and those that did not (6.7 vs 6.5mm; p=0.48) and PR were comparable
when the transfer was in the upper or middle third
of the cavity. The IR did not differ when embryos were transferred into the
upper, middle or lower third of the uterine cavity. Outcome was analyzed
separately based on the day of transfer (cleavage
vs blastocyst stage) and the IR did not differ based on the location of the
transfer.
CONCLUSIONS:
Transfer depth does not affect implantation and
pregnancy rates when the ET is in the middle or upper third of the uterus.
沒有留言:
張貼留言