輕度子宮內膜異位與試管嬰兒懷孕率之關聯

輕度子宮內膜異位可能下降胚胎受孕率及著床率

http://humrep.oxfordjournals.org/content/17/5/1135.full

Table I.

Summary of studies which provide data on fertilization rates (cleaving embryos as percentage of oocytes) in women with endometriosis (generally minor) compared with tubal infertility as controls

Stimulation used/author and year of publication	Tubal		Endometriosis		P-value
	Oocytes	Embryos (%)	Oocytes	Embryos (%)
aP < 0.05, χ2 = 4.496.
bP < 0.0001, χ2 = 761.
Unstimulated cycles
Mahmood et al., 1991a	8	5 (62)	19	10 (52)
Cahill et al., 1997	59	41 (69)	28	13 (46)	0.04
Total	67	46 (69)	47	23 (49)a
Gonadotrophin-stimulated cycles
Mahadevan et al., 1983	594	476 (80)	32	28 (87)
Wardle et al., 1985	149	77 (52)	82	22 (27)	0.001
Matson and Yovich, 1986	174	132 (75)	547	420 (77)
Dlugi et al., 1989	81	69 (85)	20	9 (45)	0.001
Mills et al., 1992	937	642 (68)	643	306 (47)	0.001
Lelaider et al., 1993	7181	5726 (80)	784	382 (48)	0.001
Simon et al., 1994	1162	670 (58)	922	401 (43)	0.001
Bergendal et al., 1998	1068	836 (78)	702	422 (60)	0.0001
Hull et al., 1998	8517	5118 (60)	2559	1421 (55)	0.001
Azem et al., 1999	1041	729 (70)	1398	559 (40)	0.001
Total	20 904	14 475 (69)	7689	3970 (52)b

What is the optimal medical management of infertility and minor endometriosis?

Table II.

Summary of studies which provide data on implantation rates (gestational sacs with fetal heart as percentage of embryos transferred) in women with endometriosis (generally minor) compared with controls (tubal and/or unexplained infertility)

Stimulation used/author and year of publication	Controls		Endometriosis		P-value
	Embryos	Sacs (%)	Embryos	Sacs (%)
aIn this abstract, numerical data were not supplied. These data are not considered in the total.
bP = 0.02, χ2 = 5.422.
Unstimulated cycles
Cahill et al., 1997	77	7 (9)	23	1 (4)
Gonadotrophin-stimulated cycles
Yovich et al., 1988	110	9 (8)	116	1 (1)
Simon et al., 1994	329	44 (13)	275	16 (6)
Geber et al., 1995a	–	–(23)	–	– (22)
Arici et al., 1996	531	43 (8)	180	5 (3)	0.013
Hull et al., 1998	2328	310 (13)	769	110 (14)
Bergendal et al., 1998	205	47 (23)	116	26 (22)
Bukulmez et al., 2001	3241	419 (13)	293	32 (11)
Total	6744	872 (13)	1749	190 (11)b