試管嬰兒實驗室空氣品質直接影響試管嬰兒懷孕率

試管嬰兒IVF實驗室污染氣體對於胚胎有不良影響
包括SO2, NO2, O3, 細微粒物質(2.5um)
污染氣體濃度越高，胚胎著床率與試管懷孕率越低
試管嬰兒I實驗室空氣品質直接影響試管嬰兒懷孕率

http://humrep.oxfordjournals.org/content/25/5/1317.long

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Figure 2

Pregnancy and live birth regression lines and 95% CI lines with concentration of three pollutants (PM_2.5, O₃ and NO₂) at the IVF lab site from retrieval till transfer (x-axis) with the probability of the three events (y-axis), pregnancy as determined by serum pregnancy test, IUP as determined by ultrasound, and live birth. This is a single-pollutant model adjusted for confounders.

Hum Reprod. 2010 May;25(5):1317-24. Epub 2010 Mar 13.

Effect of air quality on assisted human reproduction.

Legro RS, Sauer MV, Mottla GL, Richter KS, Li X, Dodson WC, Liao D.

Source

Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, 500 University Drive, H103, Hershey, PA 17033, USA.

Abstract

BACKGROUND:

Air pollution has been associated with reproductive complications. We hypothesized that declining air quality during in vitro fertilization (IVF) would adversely affect live birth rates.

METHODS:

Data from US Environmental Protection Agency air quality monitors and an established national-scale, log-normal kriging method were used to spatially estimate daily mean concentrations of criteria pollutants at addresses of 7403 females undergoing their first IVF cycle and at the their IVF labs from 2000 to 2007 in the Northeastern USA. These data were related to pregnancy outcomes.

RESULTS:

Increases in nitrogen dioxide (NO(2)) concentration both at the patient's address and at the IVF lab were significantly associated with a lower chance of pregnancy and live birth during all phases of an IVF cycle from medication start to pregnancy test [most significantly after embryo transfer, odds ratio (OR) 0.76, 95% confidence interval (CI) 0.66-0.86, per 0.01 ppm increase]. Increasing ozone (O(3)) concentration at the patient's address was significantly associated with an increased chance of live birth during ovulation induction (OR 1.26, 95% CI 1.10-1.44, per 0.02 ppm increase), but with decreased odds of live birth when exposed from embryo transfer to live birth (OR 0.62, 95% CI 0.48-0.81, per 0.02 ppm increase). After modeling for interactions of NO(2) and O(3) at the IVF lab, NO(2) remained negatively and significantly associated with live birth (OR 0.86, 95% CI 0.78-0.96), whereas O(3) was non-significant. Fine particulate matter (PM(2.5)) at the IVF lab during embryo culture was associated with decreased conception rates (OR 0.90, 95% CI 0.82-0.99, per 8 microg/m(3) increase), but not with live birth rates. No associations were noted with sulfur dioxide or larger particulate matter (PM(10)).

CONCLUSIONS:

The effects of declining air quality on reproductive outcomes after IVF are variable, cycle-dependent and complex, though increased NO(2) is consistently associated with lower live birth rates. Our findings are limited by the lack of direct measure of pollutants at homes and lab sites.