取卵後若任一卵子細胞質出現明顯平滑內質網叢
該週期形成之囊胚植入後著床率孕率明顯下降(15 vs 26%)

該週期取卵數量比一般病患還高(17 vs 14)

Fertil Steril. 2016 Oct 12. pii: S0015-0282(16)62796-6. doi: 10.1016/j.fertnstert.2016.09.006. [Epub ahead of print]

Oocytes with smooth endoplasmic reticulum clusters originate blastocysts with impaired implantation potential.

Setti AS1, Figueira RC2, Braga DP1, Azevedo MC2, Iaconelli A Jr1, Borges E Jr3.

Author information

Abstract

OBJECTIVE:

To study whether embryos derived from oocytes presenting a smooth endoplasmic reticulum cluster (SERC) are less likely to develop into blastocysts and implant.

DESIGN:

Transversal study.

SETTING:

Private university-affiliated in vitro fertilization (IVF) center.

PATIENT(S):

Total of 7,609 oocytes obtained from 743 intracytoplasmic sperm injection (ICSI) cycles.

INTERVENTION(S):

Oocytes split between the SERC-positive cycles (with at least one SERC-positive oocyte) and the SERC-negative cycles (only oocytes free of SERC).

MAIN OUTCOME MEASURE(S):

Embryo implantation.

RESULT(S):

A statistically significantly higher mean number of follicles (24.0 ± 10.5 vs. 19.6 ± 10.5), retrieved oocytes (17.8 ± 8.3 vs. 14.3 ± 8.0), and mature oocytes (13.5 ± 6.2 vs. 10.6 ± 5.9) were observed in the SERC-positive cycles as compared with SERC-negative cycles. The implantation rate was statistically significantly lower in SERC-positive cycles as compared with SERC-negative cycles (14.8% vs. 25.6%; odds ratio 0.61; 95% confidence interval, 0.44-0.86). When only cycles with in which none (0) or all the blastocysts transferred had implanted (100%) were analyzed, the mean implantation rate per transferred blastocyst in the SERC-negative group was 20.5%; no blastocysts derived from SERC-positive oocytes implanted.

CONCLUSION(S):

The occurrence of SERC impairs embryo implantation. Careful oocyte observation that takes into account the presence of SERC should be part of embryo selection strategy before transfer.