研究指出多囊PCO病患使用COH+GnRHantagonist拮抗劑+GnRHagonist破卵+全凍胚
可能是多囊未來COH趨勢

GnRHagonist破卵主要好處
可大幅下降OHSS
另一好處可誘發體內生成FSH刺激卵子進一步成熟

但仍有其他研究顯示使用GnRHagonist破卵卵質量數量較差

J Hum Reprod Sci. 2016 Jul-Sep;9(3):164-172.

Gonadotropin-releasing hormone agonist trigger is a better alternative than human chorionic gonadotropin in PCOS undergoing IVF cycles for an OHSS Free Clinic: A Randomized control trial.

Krishna D1, Dhoble S1, Praneesh G1, Rathore S1, Upadhaya A1, Rao K1.

Author information

Abstract

OBJECTIVE:

The objective of this study is to evaluate if gonadotropin-releasing hormone agonist (GnRHa) trigger is a better alternative to human chorionic gonadotropin (hCG) in polycystic ovary syndrome (PCOS) of Indian origin undergoing in vitrofertilization (IVF) cycles with GnRH antagonist for the prevention of ovarian hyperstimulation syndrome (OHSS).

DESIGN:

Prospective randomized control trial.

SETTING:

Tertiary care center.

MATERIALS AND METHODS:

A total of 227 patients diagnosed with PCOS, undergoing IVF in an antagonist protocol were recruited and randomly assigned into two groups: Group A (study group): GnRHa trigger 0.2 mg (n = 92) and Group B (control group): 250 μg of recombinant hCG as trigger (n = 101) 35 h before oocyte retrieval. We chose segmentation strategy, freezing all embryos in both the groups.

STATISTICAL ANALYSIS:

Continuous variables were expressed as mean ± standard deviation independent sample t-test and Kolmogorov-Smirnov test were used for continuous variables which were normally distributed and Mann-Whitney U-test for data not normally distributed.

MAIN OUTCOME MEASURES:

Primary outcome: OHSS (mild, moderate, and severe) rates. Secondary outcomes: Maturity rate of the oocytes, fertilization rate, availability of top quality embryos on day 3 (Grade 1 and Grade 2).

RESULTS:

The incidence of moderate to severe OHSS in the hCG group was 37.6% and 0% in the GnRHa group with P < 0.001. The GnRHa group had significantly more mature oocytes retrieved (19.1 ± 11.7 vs. 14.1 ± 4.3), more fertilized oocytes (15.6 ± 5.6 vs. 11.7 ± 3.6), and a higher number of top quality cleavage embryos on day 3 (12.9 ± 4.7 vs. 7.5 ± 4.3) than the hCG group.

CONCLUSIONS:

The most effective strategy which significantly eliminates the occurrence of OHSS in PCOS following ovarian stimulation in antagonist IVF cycles is the use of GnRHa trigger yielding more mature oocytes and good quality embryos when compared with hCG trigger.