男性體重過重對精蟲品質有不良影響
男性體重過重造成精蟲數量減低，活動力減低，活力減低，型態異常增加，DNA碎片增加，ROS增加

Reprod Biomed Online. 2016 Sep 16. pii: S1472-6483(16)30507-7. doi: 10.1016/j.rbmo.2016.08.023. [Epub ahead of print]

Does being overweight affect seminal variables in fertile men?

Taha EA1, Sayed SK2, Gaber HD1, Abdel Hafez HK1, Ghandour N3, Zahran A4, Mostafa T5.

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Abstract

The effect of being overweight on seminal variables was assesed in 165 fertile men. Participants were divided into three groups: fertile men with normal body mass index (BMI) (18.5-24.9 kg/m2), fertile overweight men (BMI 25-29.9 kg/m2) and fertile obese men (BMI >30 kg/m2). Medical history was taken, a clinical examination conducted. Semen analysis was undertaken and BMI measured. Seminal reactive oxygen species (ROS) was estimated by chemiluminescent assay, sperm vitality by the hypo-osmotic swelling test and sperm DNA fragmentation by propidium iodide staining with flowcytometry. Fertile obese men had significantly lower sperm concentration, progressive sperm motility and sperm normal morphology, with significantly higher seminal ROS and sperm DNA fragmentation compared with fertile normal-weight men and overweight men (all P < 0.05). BMI was negatively correlated with sperm concentration (r = -0.091; P = 0.014), progressive sperm motility (r = -0.697; P = 0.001), normal sperm morphology (r = -0.510; P = 0.001), sperm vitality (r = -0.586; P = 0.001), but positively correlated with sperm DNA fragmentation percentage (r = 0.799; P = 0.001) and seminal ROS (r = 0.673; P = 0.001). Increased BMI was found to affect semen parameters negatively even in fertile men.