囊胚期胚胎染色體異常率(aneuploidy)高達44%
生長速度較慢(day6 才達囊胚)之囊胚期胚胎染色體異常率高達70%

Reprod Biomed Online. 2016 Sep;33(3):398-403. doi: 10.1016/j.rbmo.2016.06.005. Epub 2016 Jun 23.

Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

Piccolomini MM1, Nicolielo M2, Bonetti TC3, Motta EL3, Serafini PC4, Alegretti JR2.

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Abstract

The aneuploidy rates in expanded blastocysts biopsied on days 5 and 6 development were assessed in women undergoing IVF followed by array comparative genomic hybridization. This study included 1171 expanded blastocysts from 465 patients. Among the 465 patients, 215 and 141 underwent embryo biopsy on day 5 and day 6 (46.2% and 30.3%, respectively), and 109 underwent biopsy on both days 5 and 6 (23.4%). The cycles of 206 women were cancelled because only aneuploidy embryos were present (44.3%). The aneuploid embryos were classified according to the type as single, double or complex aneuploidy. No differences were observed in the distributions of these three categories according to the day of the biopsy. The aneuploidy rate was also evaluated according to maternal age, and was found to be higher in older patients; however, no differences in this rate were detected between embryos biopsied on days 5 and 6 according to maternal age. Biopsy was carried out when blastocysts reached the expanded stage. The embryos biopsied on day 6 had a higher rate of aneuploidy (69.9%) than those biopsied on day 5 (61.4%); however, the euploid embryos transferred had similar chances for successful and healthy gestation.